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TRAM 1

Cat. No. 8121 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Chemical inducer of proximity for dTAG protein FKBPF36V and ecDHFR tags
化学名： (R)-1-(3-(2-((3-(4-((2,4-Diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)propyl)amino)-2-oxoethoxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for TRAM 1

TRAM 1 is a targeted relocalization activating molecule (TRAM) and chemical inducer of proximity for the dTAG protein FKBP12F36V and ecDHFR tags. Can be used to shuttle and redistribute proteins in live cells.

技术数据 for TRAM 1

分子量 1009.17
公式 C54H68N6O13
储存 Store at -20°C
纯度 ≥98% (HPLC)
InChI Key SGECTVFBOKCZAI-YZBUDRBASA-N
Smiles O=C(O[C@H](CCC1=CC(OC)=C(C=C1)OC)C2=CC(OCC(NCCCOC3=C(C=C(C=C3OC)CC4=CN=C(N=C4N)N)OC)=O)=CC=C2)[C@@H]5CCCCN5C([C@@H](CC)C6=CC(OC)=C(C(OC)=C6)OC)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TRAM 1

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100.92 100

制备储备液 for TRAM 1

以下数据基于产品分子量 1009.17。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 0.99 mL 4.95 mL 9.91 mL
5 mM 0.2 mL 0.99 mL 1.98 mL
10 mM 0.1 mL 0.5 mL 0.99 mL
50 mM 0.02 mL 0.1 mL 0.2 mL

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参考文献 for TRAM 1

参考文献是支持产品生物活性的出版物。

Ng et al (2024) Targeted protein relocalization via protein transport coupling. Nature PMID: 39294374

If you know of a relevant reference for TRAM 1, please let us know.

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关键词: TRAM 1, TRAM 1 supplier, TRAM1, targeted, relocalization, activation, molecules, dTAG, FKBP12, FKBP12F36V, cereblon, degrade, degrader, degradation, dhfr, tag, degron, chemical, inducer, of, proximity, Protein, Dimerizers, 8121, Tocris Bioscience

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