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Tramiprosate

Cat. No. 3619 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

3619 has been discontinued.

说明： Targets soluble Aβ to decrease amyloid plaque deposition. Also GABA analog
别名： Homotaurine
化学名： 3-Amino-1-propanesulfonic acid
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for Tramiprosate

Tramiprosate is a sulfated glycosaminoglycan (sGAG) mimetic that targets soluble amyloid β (Aβ) and maintains Aβ in a non-fibrillar form. Decreases Aβ42-induced neuronal death and inhibits amyloid deposition in vitro. Decreases brain amyloid plaque load by 30%, increases tau polymerization and is brain penetrant. Also a GABA analog that protects against the convulsant and cytotoxic activity of kainic acid in vivo.

技术数据 for Tramiprosate

分子量 139.17
公式 C3H9NO3S
储存 Store at +4°C
CAS Number 3687-18-1
PubChem ID 1646
InChI Key SNKZJIOFVMKAOJ-UHFFFAOYSA-N
Smiles NCCCS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Tramiprosate

参考文献是支持产品生物活性的出版物。

Fariello et al (1982) Homotaurine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid. Neurology 32 241 PMID: 7199633

Gervais et al (2007) Targeting soluble Aβ peptide with tramiprosate for the treatment of brain amyloidosis. Neurobiol.Aging 28 537 PMID: 16675063

Santa-Maria et al (2007) Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol.Neurodegen. 2 17

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关键词: Tramiprosate, Tramiprosate supplier, Sulfated, glycosaminoglycan, sGAG, Targets, soluble, Amyloid-beta, β-Amyloid, beta-Amyloid, b-amyloid, decrease, amyloid, plaque, deposition, Precursor, Protein, APP, Secretase, beta, Peptides, GABAA, GABAC, GABAB, Receptors, analogue, amyloidb, amyloidβ, Homotaurine, Amyloid, Beta, Miscellaneous, GABA, 3619, Tocris Bioscience

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