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Submit ReviewTranylcypromine hydrochloride
说明： Irreversible inhibitor of LSD1; also inhibits MAO
别名： 2-PCPA
化学名： (±)-trans-2-Phenylcyclopropylamine hydrochloride
纯度： ≥98% (HPLC)
生物活性 for Tranylcypromine hydrochloride
Tranylcypromine hydrochloride is an irreversible inhibitor of lysine-specific demethylase 1 (LSD1/BHC110) and monoamine oxidase (MAO). Inhibits histone demethylation. In combination with CHIR 99021 (Cat. No. 4423), enables reprogramming of mouse embryonic fibroblasts transduced by only two factors, Oct4 and Klf4, into induced pluripotent stem (iPS) cells.
For more information about how Tranylcypromine hydrochloride may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs
化合物库 for Tranylcypromine hydrochloride
Tranylcypromine hydrochloride is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen FDA-Approved Drugs and Tocriscreen Stem Cell Library. 了解 Tocris 化合物库的更多信息。
技术数据 for Tranylcypromine hydrochloride
| 分子量 | 169.65 |
| 公式 | C9H11N.HCl |
| 储存 | Desiccate at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 1986-47-6 |
| PubChem ID | 2723716 |
| InChI Key | ZPEFMSTTZXJOTM-OULXEKPRSA-N |
| Smiles | N[C@H]1[C@H]([C@]2=CC=CC=C2)C1.Cl |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Tranylcypromine hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 16.96 | 100 | |
| DMSO | 16.96 | 100 |
制备储备液 for Tranylcypromine hydrochloride
以下数据基于产品分子量 169.65。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.89 mL | 29.47 mL | 58.94 mL |
| 5 mM | 1.18 mL | 5.89 mL | 11.79 mL |
| 10 mM | 0.59 mL | 2.95 mL | 5.89 mL |
| 50 mM | 0.12 mL | 0.59 mL | 1.18 mL |
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产品说明书 for Tranylcypromine hydrochloride
参考文献 for Tranylcypromine hydrochloride
参考文献是支持产品生物活性的出版物。
Lee et al (2006) Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem.Biol. 13 563 PMID: 16793513
Schmidt and McCafferty (2007) trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. Biochemistry 46 4408 PMID: 17367163
Li et al (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27 2992 PMID: 19839055
If you know of a relevant reference for Tranylcypromine hydrochloride, please let us know.
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关键词: Tranylcypromine hydrochloride, Tranylcypromine hydrochloride supplier, irreversible, inhibitors, inhibits, monoamine, oxidase, A, B, MAOA, MAOB, lysine-specific, demethylase, 1, LSD1, BCH110, histone, demethylases, demethylation, oxygenases, oxidases, epigenetics, stem, cells, pluripotency, pluripotent, oct4, KDM1A, 2-PCPA, Monoamine, Oxidase, Other, Oxygenases/Oxidases, Stem, Cell, Reprogramming, Histone, Demethylases, 3852, Tocris Bioscience
8 篇 Tranylcypromine hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Tranylcypromine hydrochloride 的部分引用包括：
Li et al (2018) Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. Nat Commun 9 1420 PMID: 29650963
Sheng et al (2018) A stably self-renewing adult blood-derived induced neural stem cell exhibiting patternability and epigenetic rejuvenation. Nat Commun 9 4047 PMID: 30279449
Kearns et al (2015) Functional annotation of native enhancers with a Cas9-histone demethylase fusion. Nat Methods 12 401 PMID: 25775043
Ping et al (2018) Genome-wide DNA methylation analysis reveals that mouse chemical iPSCs have closer epigenetic features to mESCs than OSKM-integrated iPSCs. Cell Death Dis 9 187 PMID: 29416007
Liu et al (2018) CRISPR-based chromatin remodeling of the endogenous Oct4 or Sox2 locus enables reprogramming to pluripotency. Cell Stem Cell 22 252 PMID: 29358044
Sun (2018) Histone demethylase LSD1 regulates bone mass by controlling WNT7B and BMP2 signaling in osteoblasts. Bone Res 6 14 PMID: 29707403
Zhang et al (2016) Pharmacological reprogramming of fibroblasts into neural stem cells by signaling-directed transcriptional activation. Cell Stem Cell 18 653 PMID: 27133794
Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell 21 196 PMID: 20956998
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Tranylcypromine hydrochloride 的评论
平均评分: 5 (基于 2 条评论。)
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We got expected effect on cells.
By
Anonymous on 06/25/2020
分析类型： In Vitro
种属： Mouse
细胞系/组织： Neural Stem Cells
Cells are treated with 2 µM Tranylcypromine hydrochloride.
To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate).
By
Peng Liu on 12/04/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： ips
To start reprogramming, cultures were switched to reprogramming medium (ES medium supplemented with 10 mM Parnate, 3 mM Chir99021, 1 mM A83-01, and 10 mM Forskolin)
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.