Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTrifluorothymidine
说明： Thymidylate synthetase inhibitor
化学名： α,α,α-Trifluorothymidine
纯度： ≥98% (HPLC)
生物活性 for Trifluorothymidine
Trifluorothymidine is a nucleoside analog; inhibitor of thymidylate synthase. Incorporation of the triphosphate form into DNA induces DNA fragmentation. Exhibits antitumor activity.
化合物库 for Trifluorothymidine
Trifluorothymidine is also offered as part of the Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Trifluorothymidine
| 分子量 | 296.2 |
| 公式 | C10H11F3N2O5 |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 70-00-8 |
| PubChem ID | 6708818 |
| InChI Key | VSQQQLOSPVPRAZ-GFCOJPQKSA-N |
| Smiles | O=C1C(C(F)(F)F)=CN(C2O[C@H](CO)[C@@H](O)C2)C(N1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Trifluorothymidine
参考文献 for Trifluorothymidine
参考文献是支持产品生物活性的出版物。
Okayama et al (2012) Involvement of concentrative nucleoside transporter 1 in intestinal absorption of trifluorothymidine, a novel antitumor nucleoside, in rats. J.Pharmacol.Exp.Ther. 340 457 PMID: 22076553
Emura et al (2005) Potentiation of the antitumor activity of α, α, α-trifluorothymidine by the co-administration of an inhibitor of thymidine phosphorylase at a suitable molar ratio in vivo. Int.J.Oncol. 27 449 PMID: 16010427
Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell 16 142 PMID: 25658371
按产品操作查看相关产品
关键词: Trifluorothymidine, Trifluorothymidine supplier, antitumor, anticancer, nucleoside, analog, thymidylate, synthase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, Thymidylate, Synthetase, 4460, Tocris Bioscience
Trifluorothymidine 的评论
平均评分: 5 (Based on 1 Review.)
Have you used Trifluorothymidine?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
Anti-tumor activity of Trifluorothymidine was measured.
By
Anonymous on 12/23/2019
种属： Human
细胞系/组织： HeLa human cervical cancer cell line
The HeLa human cervical cancer cell line was cultured in EMEM medium with 10% FCS. Anti-tumor activity of Trifluorothymidine was measured.
The rate of tumor growth (IR) inhibition was regarded as a measure of the antitumor efficacy and was calculated using the relative tumor volume (RTV) in the drug-treated groups (T) compared to that in the control group (C) using the following equation: IR (%) = (1 – T/C) × 100.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cell Cycle and DNA Damage Research Product Guide
This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:
- Cell Cycle and Mitosis
- DNA Damage Repair
- Targeted Protein Degradation
- Ubiquitin Proteasome Pathway
- Chemotherapy Targets
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Pathways for Trifluorothymidine
Apoptosis Signaling Pathway
Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.