TY 52156

Pricing Availability   Qty
说明: S1P3 receptor antagonist
化学名: N-(4-Chlorophenyl)-3,3-dimethyl-2-oxobutanimidic 2-(4-chlorophenyl) hydrazide
纯度: ≥98% (HPLC)
说明书
引用文献 (7)
评论

生物活性 for TY 52156

TY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.

化合物库 for TY 52156

TY 52156 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for TY 52156

分子量 364.27
公式 C18H19Cl2N3O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 934369-14-9
PubChem ID 16046248
InChI Key XONRRGIRSGNWFP-UHFFFAOYSA-N
Smiles ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for TY 52156

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 36.43 100
ethanol 36.43 100

制备储备液 for TY 52156

以下数据基于产品分子量 364.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.73 mL 27.45 mL
5 mM 0.55 mL 2.75 mL 5.49 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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产品说明书 for TY 52156

分析证书/产品说明书
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参考文献 for TY 52156

参考文献是支持产品生物活性的出版物。

Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776

Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944


If you know of a relevant reference for TY 52156, please let us know.

关键词: TY 52156, TY 52156 supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Sphingosine-1-phosphate, Receptors, Cancer, Stem, Cells, 5328, Tocris Bioscience

7 篇 TY 52156 的引用文献

引用文献是使用了 Tocris 产品的出版物。 TY 52156 的部分引用包括:

Rosalinda et al (2021) Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation. Cell Physiol Biochem 55 539-552 PMID: 34473432

Rosalinda et al (2022) S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation. Cells 11 PMID: 36010601

Ma et al (2017) A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell 41 366 PMID: 28535372

Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412

Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927

Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830

Heo and Im (2019) Pro-Inflammatory Role of S1P3 in Macrophages. Biomol Ther (Seoul) PMID: 30917625


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