Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewTY 52156 is an S1P3 receptor antagonist (Ki = 110 nM); inhibits S1P-induced Ca2+ release in HUVEC cells. Suppresses FTY-720-induced S1P3 receptor-mediated bradycardia in vivo. Also inhibits S1P-induced breast cancer stem cell expansion in vitro. Orally bioavailable.
TY 52156 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
分子量 | 364.27 |
公式 | C18H19Cl2N3O |
储存 | Store at -20°C |
纯度 | ≥98% (HPLC) |
CAS Number | 934369-14-9 |
PubChem ID | 16046248 |
InChI Key | XONRRGIRSGNWFP-UHFFFAOYSA-N |
Smiles | ClC1=CC=C(/N=C(NNC2=CC=C(Cl)C=C2)/C(C(C)(C)C)=O)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
---|---|---|---|
溶解性 | |||
DMSO | 36.43 | 100 | |
ethanol | 36.43 | 100 |
以下数据基于产品分子量 364.27。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.75 mL | 13.73 mL | 27.45 mL |
5 mM | 0.55 mL | 2.75 mL | 5.49 mL |
10 mM | 0.27 mL | 1.37 mL | 2.75 mL |
50 mM | 0.05 mL | 0.27 mL | 0.55 mL |
参考文献是支持产品生物活性的出版物。
Murakami et al (2010) Sphingosine 1-phosphate (S1P) regulates vascular contraction via S1P3 receptor: investigation based on a new S1P3 receptor antagonist. Mol.Pharmacol. 77 704 PMID: 20097776
Hirata et al (2014) Sphingosine-1-phosphate promotes expansion of cancer stem cells via S1PR3 by a ligand-independent Notch activation. Nat.Commun. 25 4806 PMID: 25254944
If you know of a relevant reference for TY 52156, please let us know.
关键词: TY 52156, TY 52156 supplier, TY52156, S1P3, receptors, antagonists, antagonism, sphingosine-1-phosphate, Sphingosine-1-phosphate, Receptors, Cancer, Stem, Cells, 5328, Tocris Bioscience
引用文献是使用了 Tocris 产品的出版物。 TY 52156 的部分引用包括:
Rosalinda et al (2021) Intracellular Sphingosine-1-Phosphate Receptor 3 Contributes to Lung Tumor Cell Proliferation. Cell Physiol Biochem 55 539-552 PMID: 34473432
Rosalinda et al (2022) S1P-Induced TNF-α and IL-6 Release from PBMCs Exacerbates Lung Cancer-Associated Inflammation. Cells 11 PMID: 36010601
Ma et al (2017) A Brain-Region-Specific Neural Pathway Regulating Germinal Matrix Angiogenesis. Dev Cell 41 366 PMID: 28535372
Schuhmann et al (2015) Fingolimod (FTY720-P) Does Not Stabilize the Blood-Brain Barrier under Inflammatory Conditions in an in Vitro Model. J Neurosci 16 29454 PMID: 26690412
Hoffmann et al (2015) Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12 184 PMID: 26419927
Hübner et al (2018) Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling. Nat Commun 9 4860 PMID: 30451830
Heo and Im (2019) Pro-Inflammatory Role of S1P3 in Macrophages. Biomol Ther (Seoul) PMID: 30917625
您是否知道使用了 Tocris TY 52156 的优秀论文? 请告知我们.
目前没有该产品的评论。 Be the first to review TY 52156 and earn rewards!
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image