UAMC 00039 dihydrochloride

Name: UAMC 00039 dihydrochloride
Brand: Tocris Bioscience
SKU: 4954

Cat. No. 4954 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4954 has been discontinued.

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说明： Dipeptidyl peptidase II (DPP-II) inhibitor

化学名： (2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for UAMC 00039 dihydrochloride

UAMC 00039 dihydrochloride is a potent inhibitor of dipeptidyl peptidase II (DPP-II) (IC₅₀ = 0.48 nM). Exhibits selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV (IC₅₀ values are 78.6, 142 and 165 μM, respectively). Orally available.

技术数据 for UAMC 00039 dihydrochloride

分子量	382.76
公式	C₁₆H₂₄ClN₃O.2HCl
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	697797-51-6
PubChem ID	24757888
InChI Key	IWXMOQGMIWZNPR-CKUXDGONSA-N
Smiles	O=C([C@@H](N)CCNCC2=CC=C(Cl)C=C2)N1CCCCC1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for UAMC 00039 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for UAMC 00039 dihydrochloride

参考文献是支持产品生物活性的出版物。

Van Goethem et al (2011) Structure-activity relationship studies on isoindoline inhibitors of dipeptidyl peptidases 8 and 9 (DPP8, DPP9): is DPP8-selectivity an attainable goal? J.Med.Chem. 54 5737 PMID: 21711053

Maes et al (2007) Dipeptidyl peptidase 8/9-like activity in human leukocytes. J.Leukoc.Biol. 81 1252 PMID: 17287297

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关键词: UAMC 00039 dihydrochloride, UAMC 00039 dihydrochloride supplier, UAMC00039, dihydrochloride, dipeptidyl, peptidase, II, DPP-II, 2, inhibitors, inhibits, selective, potent, proteases, Other, Proteases, 4954, Tocris Bioscience

1 篇 UAMC 00039 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 UAMC 00039 dihydrochloride 的部分引用包括：

Klein et al (2017) Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice. Neuron 95 281 PMID: 28728022