Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewUK 383367
说明： Potent and selective BMP-1 (PCP) inhibitor
化学名： 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
纯度： ≥99% (HPLC)
生物活性 for UK 383367
UK 383367 is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase; PCP) (IC50 = 44 nM). Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).
许可信息
Sold for research purposes under agreement from Pfizer Inc.
化合物库 for UK 383367
UK 383367 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for UK 383367
| 分子量 | 324.38 |
| 公式 | C15H24N4O4 |
| 储存 | Store at -20°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 348622-88-8 |
| PubChem ID | 9818682 |
| InChI Key | ARJCBSRIPGJMAD-LLVKDONJSA-N |
| Smiles | ONC(C[C@H](C2=NC(C(N)=O)=NO2)CCCC1CCCCC1)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for UK 383367
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 32.44 | 100 |
制备储备液 for UK 383367
以下数据基于产品分子量 324.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.08 mL | 15.41 mL | 30.83 mL |
| 5 mM | 0.62 mL | 3.08 mL | 6.17 mL |
| 10 mM | 0.31 mL | 1.54 mL | 3.08 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for UK 383367
参考文献 for UK 383367
参考文献是支持产品生物活性的出版物。
Allan et al (2006) Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity. Xenobiotica 36 399 PMID: 16854779
Fish et al (2007) Potent and selective nonpeptidic inhibitors of procollagen C-proteinase. J.Med.Chem. 50 3442 PMID: 17591762
Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562 PMID: 18945617
If you know of a relevant reference for UK 383367, please let us know.
按产品操作查看相关产品
关键词: UK 383367, UK 383367 supplier, pfizer, UK383367, procollagen, c, proteinase, BMP-1, bone, morphogenic, morphogenetic, proteins, inhibitors, inhibits, Matrix, Metalloprotease, 4188, Tocris Bioscience
1 篇 UK 383367 的引用文献
引用文献是使用了 Tocris 产品的出版物。 UK 383367 的部分引用包括：
Hays et al (2018) Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats. Aging Cell 17 e12748 PMID: 29603864
您是否知道使用了 Tocris UK 383367 的优秀论文？ 请告知我们.
UK 383367 的评论
目前没有该产品的评论。 Be the first to review UK 383367 and earn rewards!
Have you used UK 383367?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Angiogenesis in Cancer Poster
This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.