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Veliparib dihydrochloride

Cat. No. 7026 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： High affinity PARP-1 and -2 inhibitor; orally bioavailable
别名： ABT-888
化学名： 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Veliparib dihydrochloride

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.

化合物库 for Veliparib dihydrochloride

Veliparib dihydrochloride is also offered as part of the Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for Veliparib dihydrochloride

分子量 317.21
公式 C13H16N4O.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 912445-05-7
PubChem ID 45480520
InChI Key DSBSVDCHFMEYBX-FFXKMJQXSA-N
Smiles C[C@]1(C2=NC3=CC=CC(C(N)=O)=C3N2)CCCN1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Veliparib dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 31.72 100
water 31.72 100

制备储备液 for Veliparib dihydrochloride

以下数据基于产品分子量 317.21。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.15 mL 15.76 mL 31.52 mL
5 mM 0.63 mL 3.15 mL 6.3 mL
10 mM 0.32 mL 1.58 mL 3.15 mL
50 mM 0.06 mL 0.32 mL 0.63 mL

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产品说明书 for Veliparib dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for Veliparib dihydrochloride

参考文献是支持产品生物活性的出版物。

Albert et al (2007) Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin.Cancer Res. 13 3033 PMID: 17505006

Donawho et al (2007) ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin.Cancer Res. 13 2728 PMID: 17473206

If you know of a relevant reference for Veliparib dihydrochloride, please let us know.

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关键词: Veliparib dihydrochloride, Veliparib dihydrochloride supplier, PARP-1, 2, inhibitors, inhibits, poly(ADP-ribose), polymerase, radiosensitizers, chemosensitizers, high, affinity, orally, bioavailable, brain, penetrant, ABT888, ABT-888, Poly(ADP-ribose), Polymerase, 7026, Tocris Bioscience

1 篇 Veliparib dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Veliparib dihydrochloride 的部分引用包括：

Mai et al (2021) NAD+ bioavailability mediates PARG inhibition-induced replication arrest, intra S-phase checkpoint and apoptosis in glioma stem cells. NAR Cancer 3 zcab044 PMID: 34806016

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.