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Verdinexor

Cat. No. 7569 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Selective exportin-1 (XPO1/CRM1) inhibitor
化学名： (2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
纯度： ≥98% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Verdinexor

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.

技术数据 for Verdinexor

分子量 442.32
公式 C18H12F6N6O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1392136-43-4
PubChem ID 71492799
InChI Key OPAKEJZFFCECPN-XQRVVYSFSA-N
Smiles C(F)(F)(F)C=1C=C(C=C(C(F)(F)F)C1)C2=NN(/C=C\C(NNC3=CC=CC=N3)=O)C=N2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Verdinexor

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.23 100
ethanol 2.21 5

制备储备液 for Verdinexor

以下数据基于产品分子量 442.32。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.3 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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参考文献 for Verdinexor

参考文献是支持产品生物活性的出版物。

Pan (2021) XPO1/CRM1 is a promising prognostic indicator for neuroblastoma and represented a therapeutic target by selective inhibitor verdinexor. J.Exp.Clin.Cancer Res. 40 255 PMID: 34384466

Perwitasari et al (2014) Verdinexor, a novel selective inhibitor of nuclear export, reduces influenza a virus replication in vitro and in vivo J.Virol. 88 10228 PMID: 24965445

If you know of a relevant reference for Verdinexor, please let us know.

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该领域的文献

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