VTP 27999 trifluoroacetate

Cat. No. 5563 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent and selective renin inhibitor

化学名： Methyl N-[2-[(R)-(3-Chlorophenyl)[(3R)-1-[[[(2S)-2-(methylamino)-3-[(3R)-tetrahydro-2H-pyran-3-yl]propyl]amino]carbonyl]-3-piperidinyl]methoxy]ethyl]carbamate trifluoroacetate

纯度： ≥97% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for VTP 27999 trifluoroacetate

VTP 27999 trifluoroacetate is a highly potent and selective renin inhibitor (IC₅₀ = 0.47 nM). Displays >1000-fold selectivity over related and unrelated off-targets. Blocks renin-stimulated ERK1/2 phosphorylation in vascular smooth muscle cells. Exhibits a different mode of action to aliskiren (Cat. No. 5491).

技术数据 for VTP 27999 trifluoroacetate

分子量	639.1
公式	C₂₆H₄₁ClN₄O₅.CF₃CO₂H
储存	Store at -20°C
纯度	≥97% (HPLC)
CAS Number	1013937-63-7
PubChem ID	121513870
InChI Key	SYWYSVAEGXHOJO-VIEYARBJSA-N
Smiles	ClC1=CC=CC([C@H](OCCNC(OC)=O)[C@]2([H])CCCN(C(NC[C@@H](NC)C[C@H]3CCCOC3)=O)C2)=C1.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VTP 27999 trifluoroacetate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	63.91	100
	DMSO	63.91	100

制备储备液 for VTP 27999 trifluoroacetate

以下数据基于产品分子量 639.1。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.56 mL	7.82 mL	15.65 mL
5 mM	0.31 mL	1.56 mL	3.13 mL
10 mM	0.16 mL	0.78 mL	1.56 mL
50 mM	0.03 mL	0.16 mL	0.31 mL

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产品说明书 for VTP 27999 trifluoroacetate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for VTP 27999 trifluoroacetate

参考文献是支持产品生物活性的出版物。

Jia et al (2011) Discovery of VTP-27999, an alkyl amine renin inhibitor with potential for clinical utility. ACS Med.Chem.Lett. 2 747 PMID: 24900262

Lu et al (2014) Renin inhibitor VTP-27999 differs from aliskiren: focus on their intracellular accumulation and the (pro)renin receptor. J.Hypertens. 32 1255 PMID: 24637873

If you know of a relevant reference for VTP 27999 trifluoroacetate, please let us know.

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