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VU 0134992

Cat. No. 6877 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Kir4.1 blocker
化学名： 2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for VU 0134992

VU 0134992 is a Kir4.1 potassium channel blocker (IC50 = 0.97 μM). Displays 10-fold selectivity for Kir4.1 over Kir4.1/5.1 concatemeric channels and >30-fold selectivity over Kir1.1, 2.1 and 2.2. Increases urine output and urinary Na+ and K+ excretion in volume-loaded rats.

化合物库 for VU 0134992

VU 0134992 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for VU 0134992

分子量 411.38
公式 C20H31BrN2O2
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 755002-90-5
PubChem ID 1319582
InChI Key OTTDLWFVHQYRDA-UHFFFAOYSA-N
Smiles CC(C)C1=CC(Br)=C(OCC(=O)NC2CC(C)(C)NC(C)(C)C2)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for VU 0134992

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 41.14 100
ethanol 41.14 100

制备储备液 for VU 0134992

以下数据基于产品分子量 411.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.15 mL 24.31 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.22 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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参考文献 for VU 0134992

参考文献是支持产品生物活性的出版物。

Kharade et al (2018) Discovery, characterization, and effects on renal fluid and electrolyte excretion of the Kir4.1 potassium channel pore blocker, VU0134992. Mol.Pharmacol. 94 926 PMID: 29895592

If you know of a relevant reference for VU 0134992, please let us know.

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关键词: VU 0134992, VU 0134992 supplier, VU0134992, inwardly, rectifying, inward, rectifier, potassium, channel, Kir, blocker, inhibitor, inhibits, Kir4.1, Inward, Potassium, Channels, 6877, Tocris Bioscience

2 篇 VU 0134992 的引用文献

引用文献是使用了 Tocris 产品的出版物。 VU 0134992 的部分引用包括：

Naoki et al (2023) Detection of astrocytic slow oscillatory activity and response to seizurogenic compounds using planar microelectrode array. Front Neurosci 16 1050150 PMID: 36703996

Christoph et al (2022) Induction of Survival of Motor Neuron (SMN) Protein Deficiency in Spinal Astrocytes by Small Interfering RNA as an In Vitro Model of Spinal Muscular Atrophy. Cells 11 PMID: 35159369

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