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Submit ReviewW-7 hydrochloride
说明： Calmodulin antagonist. Inhibits myosin light chain kinase
化学名： N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride
纯度： ≥98% (HPLC)
生物活性 for W-7 hydrochloride
W-7 hydrochloride is a calmodulin antagonist. Inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 28 μM) and myosin light chain kinase (IC50 = 51 μM). Induces shedding of platelet receptors GPVI, GPV and GPIbα.
化合物库 for W-7 hydrochloride
W-7 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for W-7 hydrochloride
| 分子量 | 377.33 |
| 公式 | C16H21ClN2O2S.HCl |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 61714-27-0 |
| PubChem ID | 124887 |
| InChI Key | OMMOSRLIFSCDBL-UHFFFAOYSA-N |
| Smiles | Cl.NCCCCCCNS(=O)(=O)C1=CC=CC2=C(Cl)C=CC=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for W-7 hydrochloride
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 1.89 | 5 温和加热 | |
| DMSO | 37.73 | 100 |
制备储备液 for W-7 hydrochloride
以下数据基于产品分子量 377.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.65 mL | 13.25 mL | 26.5 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
| 10 mM | 0.27 mL | 1.33 mL | 2.65 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.53 mL |
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产品说明书 for W-7 hydrochloride
参考文献 for W-7 hydrochloride
参考文献是支持产品生物活性的出版物。
Asano et al (1989) Divergent pharmacological effects of three calmodulin antagonists, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W 7), chlorprom. and calmidazolium, on isometric tension development and myosin light chain phosphorylation in intact bovine trachea J.Pharmacol.Exp.Ther. 251 764 PMID: 2810127
Hidaka et al (1981) N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, inhibits cell proliferation. Proc.Natl.Acad.Sci.U.S.A. 78 4354 PMID: 6945588
Itoh and Hidaka (1984) Direct interaction of calmodulin antagonists with Ca2+/calmodulin-dependent cyclic nucleotide phosphodiesterase. J.Biochem. 96 1721 PMID: 6099352
Tanaka and Hidaka (1980) Hydrophobic regions function in calmodulin-enzyme(s) interactions. J.Biol.Chem. 255 11078 PMID: 6254958
Gardiner et al (2007) Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases. J.Thromb.Haemost. 5 1530 PMID: 17445093
If you know of a relevant reference for W-7 hydrochloride, please let us know.
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关键词: W-7 hydrochloride, W-7 hydrochloride supplier, Calmodulin, antagonists, inhibitors, inhibits, myosin, light, chain, kinases, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, MLCK, Ca2+-calmodulin-dependent, phosphodiesterase, platelet, platelets, Myosin, Light, Chain, Kinase, 0369, Tocris Bioscience
16 篇 W-7 hydrochloride 的引用文献
引用文献是使用了 Tocris 产品的出版物。 W-7 hydrochloride 的部分引用包括：
Yanda et al (2017) Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease. J Biol Chem 292 17897 PMID: 28887310
Yuan et al (2015) Protein kinase G-regulated production of H2S governs oxygen sensing. Sci Signal 8 ra37 PMID: 25900831
Chang et al (2013) Areca nut-induced buccal mucosa fibroblast contraction and its signaling: a potential role in oral submucous fibrosis--a precancer condition. Psychopharmacology (Berl) 34 1096 PMID: 23349021
Midkiff et al (2011) Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways. PLoS One 6 e25395 PMID: 21966518
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Carcinogenesis 284 8726 PMID: 19141616
Mukunda et al (2014) Dimerisation of the Drosophila odorant coreceptor Orco. Neuron 8 261 PMID: 25221476
Yanes and Romero (2009) Dihydrotestosterone stimulates aldosterone secretion by H295R human adrenocortical cells. Mol Cell Endocrinol 303 50 PMID: 19428991
Schiff et al (2019) P38 inhibition reverses TGFβ1 and TNFα-induced contraction in a model of proliferative vitreoretinopathy. Commun Biol 2 162 PMID: 31069271
Hou et al (2015) The Actin Nucleator Cobl Is Controlled by Calcium and Calmodulin. Apoptosis 13 e1002233 PMID: 26334624
Bonnefond et al (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. J Biol Chem 20 535 PMID: 25627260
Araki et al (2015) Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP. J Neurosci 85 173 PMID: 25569349
Gray and Golowasch (2016) Voltage Dependence of a Neuromodulator-Activated Ionic Current. Eneuro 3 PMID: 27257619
Abdou et al (2013) The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein. Endocrinology 154 511 PMID: 23183170
Haag et al (2018) The Actin Nucleator Cobl Is Critical for Centriolar Positioning, Postnatal Planar Cell Polarity Refinement, and Function of the Cochlea. Cell Rep 24 2418 PMID: 30157434
Lopez et al (2022) Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2. Neuron 110 2283 PMID: 35649415
Dai et al (2011) Phospholipase C, Ca2+, and calmodulin signaling are required for 5-HT2A receptor-mediated transamidation of Rac1 by transglutaminase. Front Cell Neurosci 213 403 PMID: 20717650
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PN and PH cells were treated with W-7 (catalog no. 0369) and W-13 (catalog no. 0361) purchased from Tocris..
By
Anonymous on 11/17/2019
分析类型： In Vitro
种属： Mouse
细胞系/组织： PN and PH cells
PN and PH cells were treated with W-7 (catalog no. 0369) and W-13(catalog no. 0361) purchased from Tocris.
