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WAY 170523

Cat. No. 2633 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective inhibitor of MMP-13
化学名： N-[2-[4-[[[2-[(Hydroxyamino)carbonyl]-4,6-dimethylphenyl](phenylmethyl)amino]sulfonyl]phenoxy]ethyl]-2-benzofurancarboxamide
纯度： ≥99% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WAY 170523

WAY 170523 is a potent and selective inhibitor of MMP-13 (IC50 values are 17, 945, > 1000 and > 10000 nM for MMP-13, MMP-9, TACE and MMP-1 respectively).

化合物库 for WAY 170523

WAY 170523 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for WAY 170523

分子量 613.68
公式 C33H31N3O7S
储存 Desiccate at RT
纯度 ≥99% (HPLC)
CAS Number 307002-73-9
PubChem ID 9830392
InChI Key FARMEEAGJWMFSZ-UHFFFAOYSA-N
Smiles CC1=CC(C(=O)NO)=C(N(CC2=CC=CC=C2)S(=O)(=O)C2=CC=C(OCCNC(=O)C3=CC4=CC=CC=C4O3)C=C2)C(C)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WAY 170523

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 61.37 100
ethanol 61.37 100

制备储备液 for WAY 170523

以下数据基于产品分子量 613.68。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.63 mL 8.15 mL 16.3 mL
5 mM 0.33 mL 1.63 mL 3.26 mL
10 mM 0.16 mL 0.81 mL 1.63 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

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产品说明书 for WAY 170523

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for WAY 170523

参考文献是支持产品生物活性的出版物。

Chen et al (2000) Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design. J.Am.Chem.Soc. 122 9648

Jaffré et al (2012) beta -adrenergic receptor stimulation transactivates protease-activated receptor 1 via matrix metalloproteinase 13 in cardiac cells. Circulation 125 2993 PMID: 22610965

If you know of a relevant reference for WAY 170523, please let us know.

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关键词: WAY 170523, WAY 170523 supplier, Potent, selective, inhibitors, inhibits, MMP-13, Matrix, Metalloprotease, Matrixins, Metalloproteinase, MMP, Proteinases, Proteases, WAY170523, 2633, Tocris Bioscience

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