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Submit ReviewWM 1119
说明： High affinity KAT6A (MOZ) competitive inhibitor
化学名： 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide
纯度： ≥98% (HPLC)
生物活性 for WM 1119
WM 1119 is a high affinity and competitive lysine acetyltransferase 6A (KAT6A/MOZ) inhibitor (Kd = 2 nM), which displays >250-fold affinity for KAT6A compared to KAT5 and KAT7. WM 1119 induces cell-cycle exit and cellular senescence, and inhibits growth of B-cell lymphoma cells in vitro (IC50 = 0.25 μM). WM 1119 also reduces H3K9ac in tumor cells, and decreases tumor burden and spleen weight in a mouse lymphoma model.
许可信息
Sold under license from Monash University
External Portal Information for WM 1119
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of WM 1119 is reviewed on chemicalprobes.org and the SGC website.
化合物库 for WM 1119
WM 1119 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for WM 1119
| 分子量 | 389.38 |
| 公式 | C18H13F2N3O3S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2055397-28-7 |
| PubChem ID | 133080719 |
| InChI Key | QLXULUNLCRKWRD-UHFFFAOYSA-N |
| Smiles | FC1=CC(C2=CC=CC=N2)=CC(C(NNS(=O)(C3=C(C=CC=C3)F)=O)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for WM 1119
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 38.94 | 100 |
制备储备液 for WM 1119
以下数据基于产品分子量 389.38。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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产品说明书 for WM 1119
参考文献 for WM 1119
参考文献是支持产品生物活性的出版物。
Baell et al (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature. 560 253 PMID: 30069049
If you know of a relevant reference for WM 1119, please let us know.
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关键词: WM 1119, WM 1119 supplier, WM1119, KAT6A, KAT, 6A, MOZ, inhibitors, inhibits, competitive, high, affinity, lysine, histone, acetyltransferase, HAT, Histone, Acetyltransferases, 6692, Tocris Bioscience
1 篇 WM 1119 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WM 1119 的部分引用包括：
Jun et al (2020) High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening. Nat Commun 11 3455 PMID: 32661245
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.