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Submit ReviewWM 3835
说明： Lysine acetyltransferase HBO1 (KAT7) inhibitor
化学名： N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)-3-hydroxybenzenesulfonohydrazide
纯度： ≥98% (HPLC)
生物活性 for WM 3835
WM 3835 is a lysine acetyltransferase HBO1 (KAT7) inhibitor. Reduces H3K14ac levels and inhibits growth and viability of acute myeloid leukemia cell lines in vitro. Cell-permeable.
化合物库 for WM 3835
WM 3835 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。
技术数据 for WM 3835
| 分子量 | 400.42 |
| 公式 | C20H17FN2O4S |
| 储存 | Store at -20°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 2229025-70-9 |
| PubChem ID | 134581412 |
| InChI Key | KVJFJJXCBRSCDY-UHFFFAOYSA-N |
| Smiles | CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC(O)=CC=C3)=O)=O)=C1F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for WM 3835
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 40.04 | 100 | |
| ethanol | 20.02 | 50 |
制备储备液 for WM 3835
以下数据基于产品分子量 400.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.5 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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产品说明书 for WM 3835
参考文献 for WM 3835
参考文献是支持产品生物活性的出版物。
MacPherson et al (2019) HBO1 is required for the maintenance of leukaemia stem cells. Nature 577 299 PMID: 31827282
If you know of a relevant reference for WM 3835, please let us know.
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关键词: WM 3835, WM 3835 supplier, WM3835, Lysine, acetyl, transferase, inhibitors, inhibits, KAT7, HBO1, histone, HATs, MYST2, Histone, Acetyltransferases, 7366, Tocris Bioscience
1 篇 WM 3835 的引用文献
引用文献是使用了 Tocris 产品的出版物。 WM 3835 的部分引用包括：
Lancho et al (2023) A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia. Blood Cancer Discov. 4 12 PMID: 36322781
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WM 3835 的评论
平均评分: 5 (Based on 1 Review.)
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Block Hbo1.
By
Anonymous on 11/15/2024
分析类型： In Vivo
种属： Mouse
细胞系/组织： mouse brain
10mg/kg injection to mice for 10 days
We test Hbo1 inhibitor using HBO1 western blot. First lane is ctrl group. Lane 2 and 3 are WM 3835 injection groups.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.