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WM 8014

Cat. No. 6693 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective KAT6A and KAT6B inhibitor
化学名： N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide
纯度： ≥98% (HPLC)
说明书
引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for WM 8014

WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC50 values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G1/G0 in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.

许可信息

Sold under license from Monash University

化合物库 for WM 8014

WM 8014 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for WM 8014

分子量 384.42
公式 C20H17FN2O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 2055397-18-5
PubChem ID 133053564
InChI Key PHHZKBMVRPULAW-UHFFFAOYSA-N
Smiles CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC=CC=C3)=O)=O)=C1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WM 8014

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 7.69 20
ethanol 3.84 10

制备储备液 for WM 8014

以下数据基于产品分子量 384.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
0.2 mM 13.01 mL 65.03 mL 130.07 mL
1 mM 2.6 mL 13.01 mL 26.01 mL
2 mM 1.3 mL 6.5 mL 13.01 mL
10 mM 0.26 mL 1.3 mL 2.6 mL

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参考文献 for WM 8014

参考文献是支持产品生物活性的出版物。

Baell et al (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560 253 PMID: 30069049

If you know of a relevant reference for WM 8014, please let us know.

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关键词: WM 8014, WM 8014 supplier, WM8014, potent, selective, KAT6A, KAT6B, inhibitors, inhibits, histone, lysine, acetyltransferase, MOZ, MYST3, in, vitro, HAT, Histone, Acetyltransferases, 6693, Tocris Bioscience

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Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.