WM 8014

Cat. No. 6693 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective KAT6A and KAT6B inhibitor

化学名： N'-(4-Fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

纯度： ≥98% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for WM 8014

WM 8014 is a potent and selective lysine acetyltransferase KAT6A and KAT6B inhibitor (IC₅₀ values are 8 and 28 nM, respectively). Exhibits > 10-fold selectivity for KAT6A/B over KAT7 and KAT5, and no significant activity against KAT8, KAT2A/2B, and KAT3A/B. Induces cell cycle arrest in G₁/G₀ in MEFs and inhibits proliferation of lymphoma cells in vitro. Cell permeant. Suitable for use in vitro.

许可信息

Sold under license from Monash University

化合物库 for WM 8014

WM 8014 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Epigenetics Library. 了解 Tocris 化合物库的更多信息。

技术数据 for WM 8014

分子量	384.42
公式	C₂₀H₁₇FN₂O₃S
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	2055397-18-5
PubChem ID	133053564
InChI Key	PHHZKBMVRPULAW-UHFFFAOYSA-N
Smiles	CC1=CC(C2=CC=CC=C2)=CC(C(NNS(=O)(C3=CC=CC=C3)=O)=O)=C1F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for WM 8014

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	7.69	20
	ethanol	3.84	10

制备储备液 for WM 8014

以下数据基于产品分子量 384.42。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
0.2 mM	13.01 mL	65.03 mL	130.07 mL
1 mM	2.6 mL	13.01 mL	26.01 mL
2 mM	1.3 mL	6.5 mL	13.01 mL
10 mM	0.26 mL	1.3 mL	2.6 mL

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产品说明书 for WM 8014

分析证书/产品说明书

化学品安全技术说明书

参考文献 for WM 8014

参考文献是支持产品生物活性的出版物。

Baell et al (2018) Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature 560 253 PMID: 30069049

If you know of a relevant reference for WM 8014, please let us know.

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关键词: WM 8014, WM 8014 supplier, WM8014, potent, selective, KAT6A, KAT6B, inhibitors, inhibits, histone, lysine, acetyltransferase, MOZ, MYST3, in, vitro, HAT, Histone, Acetyltransferases, 6693, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.