XRP44X

Discontinued Product

3101 has been discontinued.

View all Ras GTPases products.
说明: Ras-Net (Elk-3) pathway inhibitor; also microtubule depolymerization agent and angiogenesis inhibitor
化学名: 1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine
纯度: ≥99% (HPLC)
说明书
引用文献
评论
文献 (4)
通路 (1)

生物活性 for XRP44X

Ras-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.

技术数据 for XRP44X

分子量 380.87
公式 C21H21ClN4O
储存 Store at RT
纯度 ≥99% (HPLC)
CAS Number 729605-21-4
PubChem ID 10339779
InChI Key NPHPNBGYPKBDDB-UHFFFAOYSA-N
Smiles CC1=NN(C2=CC=CC=C2)C(C(N3CCN(C4=CC(Cl)=CC=C4)CC3)=O)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for XRP44X

参考文献是支持产品生物活性的出版物。

Wasylyk et al (2008) Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 1275 PMID: 18316589

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关键词: XRP44X, XRP44X supplier, Ras-Net, pathway, inhibitors, inhibits, Antiangiogenics, microtubule, depolymerization, depolymerisation, agent, MAPK, Signaling, Signalling, G, Proteins, Small, Mitogen-Activated, Protein, Kinases, Tau, Tubulin, Microtubules, Other, Mitosis, Ras, GTPases, 3101, Tocris Bioscience

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*请注意,Tocris 仅会向正规科研企业/机构地址发送文献。


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