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(Z-LL)2 ketone

Cat. No. 5630 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5630 has been discontinued.

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说明： Putative inhibitor of signal peptide peptidase
化学名： 2,2'-(2-Oxo-1,3-propanediyl)bis[N-[(phenylmethoxy)carbonyl]-L-leucyl-L-leucinamide
纯度： ≥95% (HPLC)
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引用文献
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生物活性 技术数据 说明书 参考文献

生物活性 for (Z-LL)2 ketone

Putative inhibitor of signal peptide peptidase; inhibits p-Prl signal peptide processing (IC50 = 50 nM). Exhibits no effect on signal peptidases or proteasome activity. Reduces HSV-1 replication in vitro and in vivo.

技术数据 for (Z-LL)2 ketone

分子量 809
公式 C43H64N6O9
储存 Store at -20°C
纯度 ≥95% (HPLC)
CAS Number 313664-40-3
PubChem ID 44449123
InChI Key JTVCWQUNPMKMER-BQYLNSIHSA-N
Smiles O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(NCC(CNC([C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)OCC1=CC=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for (Z-LL)2 ketone

参考文献是支持产品生物活性的出版物。

Weihofen et al (2000) Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. J.Biol.Chem. 275 30951 PMID: 10921927

Allen et al (2014) Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo. Exp.Eye Res. 123 8 PMID: 24768597

Weihofen et al (2003) Targeting presenilin-type aspartic protease signal peptide peptidase with γ-secretase inhibitors. J.Biol.Chem. 278 16528 PMID: 12621027

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关键词: (Z-LL)2 ketone, (Z-LL)2 ketone supplier, (Z-LL)2ketone, putative, inhibitors, inhibits, signal, peptides, peptidases, p-prl, prolactin, hsv-1, Other, Proteases, 5630, Tocris Bioscience

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