Z-VRPR-FMK trifluoroacetate salt

Name: Z-VRPR-FMK trifluoroacetate salt
Brand: Tocris Bioscience
SKU: 4645

Cat. No. 4645 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4645 has been discontinued.

View all Other Proteases products.

说明： Irreversible MALT1 inhibitor

纯度： ≥95% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for Z-VRPR-FMK trifluoroacetate salt

Z-VRPR-FMK trifluoroacetate salt is an irreversible MALT1 inhibitor. Suppresses T cell activation-induced cleavage of Bcl-10 in a dose-dependent manor. Reduces Jurkat cell adhesion to fibronectin. Cell permeable.

This peptide is supplied in gross weight.

许可信息

Sold under licence from UNIL under the licenced patents

Important Information for Z-VRPR-FMK trifluoroacetate salt

This product is sold as a TFA salt. The stoichiometry of the salt and hydration levels vary from batch to batch. This product is sold in gross weight with the batch specific Net Product Content (free base) available on the Certificate of Analysis.

技术数据 for Z-VRPR-FMK trifluoroacetate salt

M. Wt	676.79 (Free Base)
公式	C₃₁H₄₉FN₁₀O₆.xCF₃CO₂H
序列	VRPR (Modifications: Val-1 = Z-Val, Arg-4 = DL-Arg-fluoromethylketone)
储存	Store at -20°C
纯度	≥95% (HPLC)
PubChem ID	121513848
InChI Key	WIPHXOQUHDJLCU-WTJMUODPSA-N
Smiles	OC(=O)C(F)(F)F.CC(C)[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)NC(CCCNC(N)=N)C(=O)CF

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for Z-VRPR-FMK trifluoroacetate salt

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Z-VRPR-FMK trifluoroacetate salt

参考文献是支持产品生物活性的出版物。

Rebeaud et al (2008) The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat.Immunol. 9 272 PMID: 18264101

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关键词: Z-VRPR-FMK trifluoroacetate salt, Z-VRPR-FMK trifluoroacetate salt supplier, MALT1, inhibitors, inhibits, NFKB, NFKappaB, NFκB, paracaspase, lymphomagenesis, ZVRPRFMK, Other, Proteases, 4645, Tocris Bioscience

1 篇 Z-VRPR-FMK trifluoroacetate salt 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Z-VRPR-FMK trifluoroacetate salt 的部分引用包括：

Grigoryeva et al (2021) Human macrophages utilize a wide range of pathogen recognition receptors to recognize Legionella pneumophila, including Toll-Like Receptor 4 engaging Legionella lipopolysaccharide and the Toll-like Receptor 3 nucleic-acid sensor PLos Pathog 17 e1009781 PMID: 34280250