Zacopride hydrochloride

Cat. No. 1795 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly potent 5-HT₃ antagonist; also 5-HT₄ agonist

化学名： (±)-4-Amino-N-1-azabicyclo[2.2.2]oct-3-yl-5-chloro-2-methoxybenzamide hydrochloride

纯度： ≥99% (HPLC)

引用文献 (3)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Zacopride hydrochloride

Zacopride hydrochloride is a highly potent 5-HT₃ receptor antagonist (K_i = 0.38 nM) and 5-HT₄ receptor agonist (K_i = 373 nM). Antiemetic and anxiolytic following systemic administration in vivo.

化合物库 for Zacopride hydrochloride

Zacopride hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Zacopride hydrochloride

分子量	346.26
公式	C₁₅H₂₀ClN₃O₂.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	101303-98-4
PubChem ID	9928181
InChI Key	ITXVOUSORXSTQH-UHFFFAOYSA-N
Smiles	Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)NC1CN2CCC1CC2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Zacopride hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	34.63	100
	DMSO	34.62	100

制备储备液 for Zacopride hydrochloride

以下数据基于产品分子量 346.26。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.89 mL	14.44 mL	28.88 mL
5 mM	0.58 mL	2.89 mL	5.78 mL
10 mM	0.29 mL	1.44 mL	2.89 mL
50 mM	0.06 mL	0.29 mL	0.58 mL

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产品说明书 for Zacopride hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Zacopride hydrochloride

参考文献是支持产品生物活性的出版物。

Cohen et al (1989) Comparison of the 5-HT₃ receptor antagonist properties of ICS 205-930, GR38032F and zacopride. J.Pharmacol.Exp.Ther. 248 197 PMID: 2521513

Costall et al (1988) Zacopride: anxiolytic profile in rodent and primate models of anxiety. J.Pharm.Pharmacol. 40 302 PMID: 2900320

Kii and Ito (1997) Effects of 5-HT₄-receptor agonists, cisapride, mosapride citrate, and zacopride, on cardiac action potentials in guinea pig isolated papillary muscles. J.Cardiovasc.Pharmacol. 29 670 PMID: 9213211

Nagakura et al (1999) Pharmacological properties of a novel gastrointestinal prokinetic benzamide selective for human 5-HT₄ receptor versus human 5-HT₃ receptor. Pharmacol.Res. 39 375 PMID: 10328995

If you know of a relevant reference for Zacopride hydrochloride, please let us know.

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关键词: Zacopride hydrochloride, Zacopride hydrochloride supplier, 5-HT4, agonists, potent, 5-HT3, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 1795, Tocris Bioscience

3 篇 Zacopride hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Zacopride hydrochloride 的部分引用包括：

Wang et al (2016) 5-HTR3 and 5-HTR4 located on the mitochondrial membrane and functionally regulated mitochondrialfunctions Scientific Reports 6 37336 PMID: 27874067

Ding et al (2015) The reinforcing effects of ethanol within the nucleus accumbens shell involve activation of local GABA and serotonin receptors. Toxins (Basel) 29 725 PMID: 25922425

Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Circulation 7 2336 PMID: 26114334

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