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Submit ReviewZolmitriptan
说明： Potent 5-HT1B/1D/1F agonist
化学名： (4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
纯度： ≥99% (HPLC)
生物活性 for Zolmitriptan
Zolmitriptan is a potent 5-HT1B/1D/1F agonist (Ki values are 0.63, 5.01 and 63.09 nM for h5-HT1D, h5-HT1B and h5-HT1F receptors respectively). Inhibits trigeminal nerve stimulation-mediated neurogenic plasma protein extravasation in guinea pigs; blocks long excitatory postsynaptic potentials (EPSPs) in a rat model of spinal cord injury.
化合物库 for Zolmitriptan
Zolmitriptan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Zolmitriptan
| 分子量 | 287.36 |
| 公式 | C16H21N3O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 139264-17-8 |
| PubChem ID | 60857 |
| InChI Key | ULSDMUVEXKOYBU-ZDUSSCGKSA-N |
| Smiles | CN(C)CCC2=CNC1=CC=C(C[C@H](N3)COC3=O)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Zolmitriptan
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 28.74 | 100 | |
| ethanol | 28.74 | 100 |
制备储备液 for Zolmitriptan
以下数据基于产品分子量 287.36。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.48 mL | 17.4 mL | 34.8 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
| 10 mM | 0.35 mL | 1.74 mL | 3.48 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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产品说明书 for Zolmitriptan
参考文献 for Zolmitriptan
参考文献是支持产品生物活性的出版物。
Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J.Neurophysiol. 106 925 PMID: 21653728
Pauwels et al (1997) How efficacious are 5-HT1B/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines. Neuropharmacology 36 499 PMID: 9225275
Martin et al (1997) Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br.J.Pharmacol. 121 157 PMID: 9154322
If you know of a relevant reference for Zolmitriptan, please let us know.
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关键词: Zolmitriptan, Zolmitriptan supplier, 5ht, 5-ht, serotonergics, 5ht1B, 5ht1D, 5ht1F, potent, agonists, excitatory, postsynaptic, potentials, migraine, neurogenic, plasma, protein, extravasation, 5-HT1B, Receptors, 5-HT1D, 5-HT1F, 4657, Tocris Bioscience
1 篇 Zolmitriptan 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Zolmitriptan 的部分引用包括：
Gadgaard & Jensen (2020) Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay. Biochem Pharmacol 175 PMID: 32088264
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.