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Description: Ras-Net (Elk-3) pathway inhibitor; also microtubule depolymerization agent and angiogenesis inhibitor
Chemical Name: 1-(3-Chlorophenyl)-4-[(3-methyl-1-phenyl-1H-pyrazol-5-yl)carbonyl]piperazine
Purity: ≥99% (HPLC)
Biological Activity for XRP44X
Ras-Net (Elk-3) pathway inhibitor (IC50 = 10 - 20 nM). Indirectly inhibits Net phosphorylation upstream of Erk1/2 activation. Mediates G2-M cell cycle arrest, suppresses growth of multiple cell types (IC50 ~ 2 nM), inhibits angiogenesis and acts as a microtubule depolymerizing agent in vitro.
Technical Data for XRP44X
| M. Wt | 380.87 |
| Formula | C21H21ClN4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 729605-21-4 |
| PubChem ID | 10339779 |
| InChI Key | NPHPNBGYPKBDDB-UHFFFAOYSA-N |
| Smiles | CC1=NN(C2=CC=CC=C2)C(C(N3CCN(C4=CC(Cl)=CC=C4)CC3)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for XRP44X
References for XRP44X
References are publications that support the biological activity of the product.
Wasylyk et al (2008) Inhibition of the Ras-Net (Elk-3) pathway by a novel pyrazole that affects microtubules. Cancer Res. 68 1275 PMID: 18316589
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Keywords: XRP44X, XRP44X supplier, Ras-Net, pathway, inhibitors, inhibits, Antiangiogenics, microtubule, depolymerization, depolymerisation, agent, MAPK, Signaling, Signalling, G, Proteins, Small, Mitogen-Activated, Protein, Kinases, Tau, Tubulin, Microtubules, Other, Mitosis, Ras, GTPases, 3101, Tocris Bioscience
Citations for XRP44X
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Pathways for XRP44X
Akt Signaling Pathway
The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.