Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewAZ PFKFB3 67
Description: Potent and selective PFKFB3 inhibitor
Chemical Name: (2S)-N-[4-[[3-Cyano-1-[(3,5-dimethyl-4-isoxazolyl)methyl]-1H-indol-5-yl]oxy]phenyl]-2-pyrrolidinecarboxamide
Purity: ≥98% (HPLC)
Biological Activity for AZ PFKFB3 67
AZ PFKFB3 67 is a potent and selective PFKFB3 inhibitor (IC50 values are 11, 159 and 1130 nM for PFKFB3, PFKFB2 and PFKFB1 respectively).
Compound Libraries for AZ PFKFB3 67
AZ PFKFB3 67 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.
Technical Data for AZ PFKFB3 67
| M. Wt | 455.51 |
| Formula | C26H25N5O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1704741-11-6 |
| PubChem ID | 91668554 |
| InChI Key | NDIKFKQBWGMLCA-DEOSSOPVSA-N |
| Smiles | N#CC1=CN(CC2=C(C)ON=C2C)C3=C1C=C(OC4=CC=C(NC([C@H]5NCCC5)=O)C=C4)C=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AZ PFKFB3 67
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.55 | 100 | |
| ethanol | 45.55 | 100 |
Preparing Stock Solutions for AZ PFKFB3 67
The following data is based on the product molecular weight 455.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.2 mL | 10.98 mL | 21.95 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.2 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for AZ PFKFB3 67
References for AZ PFKFB3 67
References are publications that support the biological activity of the product.
Boyd et al (2015) Structure-based design of potent and selective inhibitors of the metabolic kinase PFKFB3. J.Med.Chem. 58 3611 PMID: 25849762
If you know of a relevant reference for AZ PFKFB3 67, please let us know.
View Related Products by Product Action
Keywords: AZ PFKFB3 67, AZ PFKFB3 67 supplier, AZPFKFB367, PFKFB3, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, inhibitors, inhibits, glycolysis, 5742, Tocris Bioscience
4 Citations for AZ PFKFB3 67
Citations are publications that use Tocris products. Selected citations for AZ PFKFB3 67 include:
Zheng et al (2017) LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J 36 3325 PMID: 28963395
Mihaela et al (2022) Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition. Nat Metab 4 123-140 PMID: 35102339
Zheng et al (2022) Suppression of myeloid PFKFB3-driven glycolysis protects mice from choroidal neovascularization. Br J Pharmacol 179 5109-5131 PMID: 35830274
Satoshi et al (2021) PFKFB3-dependent glucose metabolism regulates 3T3-L1 adipocyte development. FASEB J 35 e21728 PMID: 34110658
Do you know of a great paper that uses AZ PFKFB3 67 from Tocris? Please let us know.
Reviews for AZ PFKFB3 67
There are currently no reviews for this product. Be the first to review AZ PFKFB3 67 and earn rewards!
Have you used AZ PFKFB3 67?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cancer Metabolism Research Product Guide
This product guide reviews some of the main areas in cancer metabolism research and lists around 150 products that can be used to investigate metabolic pathways in cancer including:
- Glycolysis
- Tricarboxylic Acid Cycle
- Lipidogenesis
- 1C Metabolism and Nucleic Acid Synthesis
- Drivers of Metabolic Reprogramming
- pH and Redox Balance
Cell Cycle & DNA Damage Repair Poster
In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.
Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.