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Submit Review3-Nitropropionic acid
Description: Irreversible mitochondrial respiratory complex II inhibitor
Purity: ≥97% (HPLC)
Biological Activity for 3-Nitropropionic acid
3-Nitropropionic acid is an irreversible mitochondrial respiratory complex II (succinate dehydrogenase) inhibitor; induces autophagy in SH-SY5Y cells. Recapitulates Huntington's disease-like pathology and symptoms in primate and rodent models.
Technical Data for 3-Nitropropionic acid
| M. Wt | 119.08 |
| Formula | C3H5NO4 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 504-88-1 |
| PubChem ID | 1678 |
| InChI Key | WBLZUCOIBUDNBV-UHFFFAOYSA-N |
| Smiles | OC(CC[N+]([O-])=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for 3-Nitropropionic acid
References for 3-Nitropropionic acid
References are publications that support the biological activity of the product.
de Oca Balderas et al (2013) Mitochondrial impairment induced by 3-nitropropionic acid is enhanced by endogenous metalloprotease activity inhibition in cultured rat striatal neurons. Neurosci.Lett. PMID: 23643981
Solesio et al (2013) 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br.J.Pharmacol. 168 63 PMID: 22509855
Huang et al (2005) 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem. 28 5965 PMID: 16371358
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Citations for 3-Nitropropionic acid
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Currently there are no citations for 3-Nitropropionic acid.
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