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6-Hydroxy-DL-DOPA

Cat. No. 5740 Submit a Review Datasheet / COA / SDS

Discontinued Product

5740 has been discontinued.

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Description: Allosteric inhibitor of RAD52; also APE1 inhibitor
Chemical Name: 2,5-Dihydroxy-DL-tyrosine
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for 6-Hydroxy-DL-DOPA

6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.

Technical Data for 6-Hydroxy-DL-DOPA

M. Wt 213.19
Formula C9H11NO5
Storage Store at -20°C
CAS Number 21373-30-8
PubChem ID 107794
InChI Key YLKRUSPZOTYMAT-UHFFFAOYSA-N
Smiles OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for 6-Hydroxy-DL-DOPA

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for 6-Hydroxy-DL-DOPA

References are publications that support the biological activity of the product.

Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID: 20809131

Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID: 19484131

Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID: 26548611

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Citations for 6-Hydroxy-DL-DOPA

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Literature in this Area

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