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Ac4GlcNAlk

Cat. No. 7750 Submit a Review Datasheet / COA / SDS
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Description: Metabolic chemical reporter for studying glycosylation and glycoproteins
Chemical Name: 2-Deoxy-2-[(1-oxo-4-pentyn-1-yl)amino]-D-glucopyranose-1,3,4,6-tetraacetate
Purity: ≥95% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ac4GlcNAlk

Ac4GlcNAlk is a metabolic chemical reporter (MCR) for studying cell surface glycosylation. It is used for identification of O-GlcNAc modified proteins. In cells expressing the engineered pyrophosphorylase, mut-AGX1, Ac4GlcNAlk is efficiently converted into UDP-GlcNAlk which is incorporated into GlcNAlk-containing glycoproteins.

Technical Data for Ac4GlcNAlk

M. Wt 427.41
Formula C19H25NO10
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 1361993-37-4
PubChem ID 101797984
InChI Key PODQGPKRSTUNAT-ULAPBGCESA-N
Smiles CC(OC[C@H]1OC([C@@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)NC(CCC#C)=O)OC(C)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ac4GlcNAlk

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.74 100

Preparing Stock Solutions for Ac4GlcNAlk

The following data is based on the product molecular weight 427.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.34 mL 11.7 mL 23.4 mL
5 mM 0.47 mL 2.34 mL 4.68 mL
10 mM 0.23 mL 1.17 mL 2.34 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Molarity Calculator

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Reconstitution Calculator

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References for Ac4GlcNAlk

References are publications that support the biological activity of the product.

Cioce et al (2021) Optimization of metabolic oligosaccharide engineering with Ac4GalNAlk and Ac4GlcNAlk by an engineered pyrophosphorylase. ACS Chem.Biol. 16 1961 PMID: 33835779

If you know of a relevant reference for Ac4GlcNAlk, please let us know.

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Keywords: Ac4GlcNAlk, Ac4GlcNAlk supplier, bio-orthogonal, glycosylation, glycoproteins, probes, labeling, labelling, metabolic, chemical, reporter, MCR, O-GlcNAc, Glycobiology, Probes, Post-translational, Modifications, 7750, Tocris Bioscience

Citations for Ac4GlcNAlk

Citations are publications that use Tocris products.

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