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Submit ReviewAEBSF
Description: Broad spectrum, irreversible inhibitor of serine proteases
Chemical Name: 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for AEBSF
AEBSF is a broad spectrum, irreversible inhibitor of serine proteases. Also inhibits NADPH oxidase activation in vitro. Attenuates airway inflammation in a mouse model of airway allergy.
Compound Libraries for AEBSF
AEBSF is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for AEBSF
| M. Wt | 239.69 |
| Formula | C8H10FNO2S.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 30827-99-7 |
| PubChem ID | 186136 |
| InChI Key | WRDABNWSWOHGMS-UHFFFAOYSA-N |
| Smiles | NCCC1=CC=C(S(=O)(F)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for AEBSF
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 23.97 | 100 | |
| DMSO | 23.97 | 100 |
Preparing Stock Solutions for AEBSF
The following data is based on the product molecular weight 239.69. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.17 mL | 20.86 mL | 41.72 mL |
| 5 mM | 0.83 mL | 4.17 mL | 8.34 mL |
| 10 mM | 0.42 mL | 2.09 mL | 4.17 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.83 mL |
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Product Datasheets for AEBSF
References for AEBSF
References are publications that support the biological activity of the product.
Diatchuk et al (1997) Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J.Biol.Chem. 272 13292 PMID: 9148950
Saw et al (2012) Serine protease inhibitor attenuates ovalbumin induced inflammation in mouse model of allergic airway disease. PLoS ONE 7 e41107 PMID: 22829914
If you know of a relevant reference for AEBSF, please let us know.
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Keywords: AEBSF, AEBSF supplier, broad, spectrum, irreversible, serine, proteases, inhibitors, inhibits, trypsin, chymotrypsin, plasmin, thrombin, kallikreins, Other, Proteases, 5175, Tocris Bioscience
1 Citation for AEBSF
Citations are publications that use Tocris products. Selected citations for AEBSF include:
Xianglan et al (2019) Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol 144 426-441.e3 PMID: 30872118
Do you know of a great paper that uses AEBSF from Tocris? Please let us know.
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