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AEG 40730 dihydrochloride

Cat. No. 5330 Submit a Review Datasheet / COA / SDS

Discontinued Product

5330 has been discontinued.

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Description: IAP antagonist; induces apoptosis
Chemical Name: 222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide, diethyl ether with 2,4-hexadiyne-1.6-diol dihydrochloride
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for AEG 40730 dihydrochloride

AEG 40730 dihydrochloride is an IAP antagonist; binds to the BIR3 domain of cIAP1, cIAP2 and XIAP with nanomolar affinity. Reduces cIAP1, cIAP2 and XIAP protein levels in human breast cancer MDA-MB-231 cells. Induces apoptosis in combination with TNF, and potentiates TRAIL-mediated apoptosis in human colorectal carcinoma HCT 116 cells. Cell permeable.

Technical Data for AEG 40730 dihydrochloride

M. Wt 1120.06
Formula C52H68F6N8O8.2HCl
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 1883545-50-3
PubChem ID 91826085
InChI Key CDGBXBVDDLOZGF-CLHBFWEXSA-N
Smiles O=C([C@H](C)NC)N[C@@H]([C@H](OCC#CC#CCO[C@H](C)[C@H](NC([C@H](C)NC)=O)C(N2[C@H](CN(CCC3=CC=CC=C3)C(C(F)(F)F)=O)CCC2)=O)C)C(N1[C@H](CN(C(C(F)(F)F)=O)CCC4=CC=CC=C4)CCC1)=O.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for AEG 40730 dihydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for AEG 40730 dihydrochloride

References are publications that support the biological activity of the product.

Beug et al (2014) Smac mimetics and innate immune stimuli synergize to promote tumor death. Nat.Biotechnol. 32 182 PMID: 24463573

Galbán et al (2009) Cytoprotective effects of IAPs revealed by a small molecule antagonist. Biochem.J. 417 765 PMID: 18851715

Bertrand et al (2008) cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol. Cell 30 689 PMID: 18570872

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Citations for AEG 40730 dihydrochloride

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Literature in this Area

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for AEG 40730 dihydrochloride

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.