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Submit ReviewAmyloid β-Peptide (1-40) (human)
Description: Amyloid β-protein fragment
Purity: ≥95% (HPLC)
Biological Activity for Amyloid β-Peptide (1-40) (human)
Amyloid β-Peptide (1-40) (human) is a peptide found in plaques in the brains of patients with Alzheimer's disease. Shown to have both neurotrophic and neurotoxic effects.
Technical Data for Amyloid β-Peptide (1-40) (human)
| M. Wt | 4329.86 |
| Formula | C194H295N53O58S |
| Sequence | DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 131438-79-4 |
| PubChem ID | 16135555 |
| InChI Key | FEWOUVRMGWFWIH-ILZZQXMPSA-N |
| Smiles | [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Amyloid β-Peptide (1-40) (human)
| Solubility | Soluble to 1 mg/ml in water |
Product Datasheets for Amyloid β-Peptide (1-40) (human)
References for Amyloid β-Peptide (1-40) (human)
References are publications that support the biological activity of the product.
Cleary et al (1995) Beta-amyloid(1-40) effects on behavior and memory. Brain Res. 682 69 PMID: 7552329
Kowalska and Badellino (1994) β-Amyloid protein induces platelet aggregation and supports platelet adhesion. Biochem.Biophys.Res.Commun. 205 1829 PMID: 7811271
Miguel-Hidalgo and Cacabelos (1998) Beta-amyloid(1-40)-induced neurodegeneration in the rat hippocampal neurons of the CA1 subfield. Acta Neuropathol. 95 455 PMID: 9600591
Yankner et al (1990) Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250 279 PMID: 2218531
If you know of a relevant reference for Amyloid β-Peptide (1-40) (human), please let us know.
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Keywords: Amyloid beta-Peptide (1-40) (human), Amyloid beta-Peptide (1-40) (human) supplier, Amyloid, β-protein, beta-protein, fragment, Precursor, Protein, APP, Secretase, β-peptide, beta-peptides, b-peptides, b-amyloid, β-Amyloid, beta-Amyloid, amyloid, beta-peptide, (1-40), (human), amyloidbeta, amyloidb, amyloidβ, Beta, Peptides, 1191, Tocris Bioscience
1 Citation for Amyloid β-Peptide (1-40) (human)
Citations are publications that use Tocris products. Selected citations for Amyloid β-Peptide (1-40) (human) include:
Briyal et al (2015) Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience 301 1 PMID: 26022359
Do you know of a great paper that uses Amyloid β-Peptide (1-40) (human) from Tocris? Please let us know.
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Literature in this Area
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Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.