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Submit ReviewAmyloid β-peptide (25-35) (human)
Description: Human amyloid β-protein fragment functionally required for neurotoxicity
Purity: ≥95% (HPLC)
Biological Activity for Amyloid β-peptide (25-35) (human)
Amyloid β-peptide (25-35) (human) is a fragment of human amyloid β-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
Technical Data for Amyloid β-peptide (25-35) (human)
| M. Wt | 1060.27 |
| Formula | C45H81N13O14S |
| Sequence | GSNKGAIIGLM |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 131602-53-4 |
| PubChem ID | 10843733 |
| InChI Key | WIHBNMPFWRHGDF-SLVFWPMISA-N |
| Smiles | [H]NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Amyloid β-peptide (25-35) (human)
| Solubility | Soluble to 0.50 mg/ml in water |
Product Datasheets for Amyloid β-peptide (25-35) (human)
References for Amyloid β-peptide (25-35) (human)
References are publications that support the biological activity of the product.
Rush et al (1992) Intracerebral β-amyloid(25-35) produces tissue damage: is it neurotoxic? Neurobiol.Aging 13 591 PMID: 1281289
Schenk et al (1995) Therapeutic approaches related to amyloid-β peptide and Alzheimer's Disease J.Med.Chem. 38 4141 PMID: 7473539
Yankner et al (1990) Neurotrophic and neurotoxic effects of amyoid β protein: reversal by tachykinin neuropeptides. Science 250 279 PMID: 2218531
If you know of a relevant reference for Amyloid β-peptide (25-35) (human), please let us know.
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1 Citation for Amyloid β-peptide (25-35) (human)
Citations are publications that use Tocris products. Selected citations for Amyloid β-peptide (25-35) (human) include:
Ostrovskaya et al (2014) Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J.Biomed.Sci. 21 74 PMID: 25096780
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Alzheimer's Disease Poster
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