Anle138b

Cat. No. 6861 Submit a Review Datasheet / COA / SDS

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Description: Oligomeric aggregation inhibitor; inhibits prion protein and α-synuclein aggregate formation

Chemical Name: 3-(1,3-Benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole

Purity: ≥98% (HPLC)

Datasheet

Citations

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Pathways (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Anle138b

Anle138b is an oligomeric aggregation inhibitor that inhibits formation of pathological prion protein (PrP^Sc) and α-synuclein aggregates in vitro. Anle138b prevents accumulation of PrP^Sc in brain and spleen, and prolongs survival of prion-infected mice. Anle138b exhibits neuroprotective effects in a Parkinson's disease mouse model and improves motor performance in an α-synucleinopathy model. Orally bioavailable and brain penetrant.

Technical Data for Anle138b

M. Wt	343.18
Formula	C₁₆H₁₁BrN₂O₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	882697-00-9
PubChem ID	44608289
InChI Key	RCQIIBJSUWYYFU-UHFFFAOYSA-N
Smiles	BrC1=CC=CC(=C1)C1=CC(=NN1)C1=CC=C2OCOC2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Anle138b

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	17.16	50

Preparing Stock Solutions for Anle138b

The following data is based on the product molecular weight 343.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.83 mL	29.14 mL	58.28 mL
2.5 mM	1.17 mL	5.83 mL	11.66 mL
5 mM	0.58 mL	2.91 mL	5.83 mL
25 mM	0.12 mL	0.58 mL	1.17 mL

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Product Datasheets for Anle138b

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Anle138b

References are publications that support the biological activity of the product.

Wagner et al (2013) Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease. Acta Neuropathol. 125 795 PMID: 23604588

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Citations for Anle138b

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Pathways for Anle138b

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.