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Submit ReviewArgatroban
Description: Potent thrombin inhibitor
Chemical Name: (2R,4R)-1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-2-piperidinecarboxylic acid
Purity: ≥99% (HPLC)
Biological Activity for Argatroban
Argatroban is a potent inhibitor of thrombin mediated fibrinogen cleavage (Ki = 19 nM). Competitive inhibitor of thrombin-induced platelet activation and clotting. Shown to exhibit antithrombotic activity in animal models.
This compound is a mixture of 2 diastereomers (approximate ratio 65/35).
Compound Libraries for Argatroban
Argatroban is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Argatroban
| M. Wt | 508.63 |
| Formula | C23H36N6O5S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 74863-84-6 |
| PubChem ID | 6604954 |
| InChI Key | CQTDZUSQSTUZDA-UHFFFAOYSA-M |
| Smiles | O=C(N1[C@@H]([C@@](O)=O)C[C@H](C)CC1)[C@@H](NS(C2=CC=CC3=C2NCC(C)C3)(=O)=O)CCCNC(N)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Argatroban
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.86 | 100 | |
| 1eq. HCl | 5.09 | 10 |
Preparing Stock Solutions for Argatroban
The following data is based on the product molecular weight 508.63. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.83 mL | 19.66 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.93 mL |
| 10 mM | 0.2 mL | 0.98 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.39 mL |
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Product Datasheets for Argatroban
References for Argatroban
References are publications that support the biological activity of the product.
Kikumoto et al (1984) Selective inhibition of thrombin by (2R,4R)-4-methyl-1-[N2-[(3-methyl-1,2,3,4-tetrahydro-8-quinolinyl++ +) sulfonyl]-1-arginyl)]-2-piperidinecarboxylic acid. Biochemistry 23 85 PMID: 6691968
Jang et al (1990) Prevention of platelet-rich arterial thrombosis by selective thrombin inhibition. Circulation 81 219 PMID: 2297828
Fitzgerald and Fitzgerald (1989) Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proc.Natl.Acad.Sci.USA 86 7585
If you know of a relevant reference for Argatroban, please let us know.
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Keywords: Argatroban, Argatroban supplier, Potent, inhibitors, thrombin, fibrinogen, inhibits, antithrombitic, Other, Proteases, 1637, Tocris Bioscience
Citations for Argatroban
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