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B02

Cat. No. 6392 Submit a Review Datasheet / COA / SDS
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Description: RAD51 recombinase inhibitor
Chemical Name: 3-(Phenylmethyl)-2-[(1E)-2-(3-pyridinyl)ethenyl]-4(3H)-quinazolinone
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for B02

B02 is a RAD51 recombinase inhibitor, exhibiting selectivity for human RAD51 over the E.coli homologue RecA (IC50 values are 27.4 μM and >250 μM, respectively). Inhibits homologous recombination and increases cellular sensitivity to DNA damage in vitro. Enhances the therapeutic effect of cisplatin (Cat. No. 2251) on tumor cells in vivo.

Technical Data for B02

M. Wt 339.4
Formula C22H17N3O
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1290541-46-6
PubChem ID 5738263
InChI Key GEKDQXSPTHHANP-OUKQBFOZSA-N
Smiles O=C1N(CC2=CC=CC=C2)C(/C=C/C3=CN=CC=C3)=NC4=CC=CC=C41

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for B02

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.94 100
ethanol 3.39 10

Preparing Stock Solutions for B02

The following data is based on the product molecular weight 339.4. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.95 mL 14.73 mL 29.46 mL
5 mM 0.59 mL 2.95 mL 5.89 mL
10 mM 0.29 mL 1.47 mL 2.95 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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References for B02

References are publications that support the biological activity of the product.

Huang et al (2011) Identification of specific inhibitors of human RAD51 recombinase using high-throughputscreening. ACS Chem.Biol. 6 682 PMID: 21428443

Huang et al (2012) Inhibition of homologous recombination in human cells by targeting RAD51 recombinase. J.Med.Chem. 55 3011 PMID: 22380680

Alagpulinsa et al (2014) A small-molecule inhibitor of RAD51 reduces homologous recombination and sensitizes multiple myeloma cells to dox. Front.Oncol. 4 289 PMID: 25401086

Huang and Mazin (2014) A small molecule inhibitor of human RAD51 potentiates breast cancer cell killing by therapeuticagents in mouse xenografts. PLoS One 9 e100993 PMID: 24971740

If you know of a relevant reference for B02, please let us know.

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Keywords: B02, B02 supplier, B02, RAD51, recombinase, inhibitors, inhibits, DNA,, RNA, and, Protein, Synthesis, 6392, Tocris Bioscience

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Literature in this Area

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