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Submit ReviewC3bot (154-182)
Description: Neurotrophic fragment of clostridial C3 protein
Biological Activity for C3bot (154-182)
C3bot (154-182) is a transferase-deficient neurotrophic fragment of clostridial C3 protein. Promotes axonal and dendritic growth and branching of hippocampal neurons at submicromolar concentrations. Also promotes reinnervation of target tissues in organotypical hippocampal/entorhinal slice cultures. Reduces levels of active neuronal RhoA by a non-enzymatic mechanism. Enhances functional recovery and regeneration in a mouse model of spinal cord injury.
Technical Data for C3bot (154-182)
| M. Wt | 3058.54 |
| Formula | C137H221N37O40S |
| Sequence | VAKGSKAGYIDPISAFAGQLEMLLPRHST |
| Storage | Store at -20°C |
| CAS Number | 1246280-79-4 |
| PubChem ID | 90488913 |
| InChI Key | COZZQWVNMFWMBN-QMBBDSMRSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for C3bot (154-182)
References for C3bot (154-182)
References are publications that support the biological activity of the product.
Holtje et al (2009) A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation. FASEB J. 23 1115 PMID: 19047066
Boato et al (2010) C3 peptide enhances recovery from spinal cord injury by improved regenerative growth of descending fiber tracts. J.Cell Science 123 1652
Just et al (2011) Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn-Schmied.Arch.Pharmacol. 383 247
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Keywords: C3bot (154-182), C3bot (154-182) supplier, clostridium, clostridial, C3, protein, neurotrophic, axon, dendrite, outgrowth, transferase-deficient, peptide, fragment, spinal, cord, injury, injuries, c3, bot154-182, Neuronal, Metabolism, 4123, Tocris Bioscience
Citations for C3bot (154-182)
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