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CAM 833

Cat. No. 7457 Submit a Review Datasheet / COA / SDS
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Description: Selective orthosteric inhibitor of the BRCA2-RAD51 interaction
Chemical Name: N-(2-((2S,4R)-2-(((S)-1-(2-Chloro-4-methoxyphenyl)ethyl)carbamoyl)-4-hydroxypyrrolidin-1-yl)-2-oxoethyl)-6-fluoroquinoline-2-carboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CAM 833

CAM 833 a selective orthosteric inhibitor of the BRCA2-RAD51 interaction (Kd of 366 nM; IC50 of 6 μM). CAM 833 has no significant off-target interactions when screened at 10 μM in the Cerep ExpresSPanel. It inhibits DNA recombinase RAD51-mediated homologous recombination through binding to RAD51 at the same site as the BRCA2 FxxA motif. In cells, CAM 833 suppresses the assembly of RAD51 into damage-induced filaments at the sites of DNA damage. CAM 833 potentiates radiation-induced cytotoxicity and poly-ADP ribose polymerase (PARP)1 inhibitor-induced growth suppression in BRCA2-wild-type cells. The product is metabolically stable, does not significantly inhibit CYP450 enzymes, and is suitable for in vivo investigation.

Technical Data for CAM 833

M. Wt 528.97
Formula C26H26ClFN4O5
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2758364-02-0
InChI Key PMUWBFKMLGLUTF-KNUWZQJKSA-N
Smiles FC1=CC2=CC=C(N=C2C=C1)C(NCC(N3[C@@H](C[C@H](C3)O)C(N[C@H](C4=C(C=C(C=C4)OC)Cl)C)=O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CAM 833

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.9 100
ethanol 2.64 5

Preparing Stock Solutions for CAM 833

The following data is based on the product molecular weight 528.97. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.89 mL 9.45 mL 18.9 mL
5 mM 0.38 mL 1.89 mL 3.78 mL
10 mM 0.19 mL 0.95 mL 1.89 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References for CAM 833

References are publications that support the biological activity of the product.

Scott et al (2021) A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death. Cell Chem.Biol. 28 835 PMID: 33662256

If you know of a relevant reference for CAM 833, please let us know.

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Keywords: CAM 833, CAM 833 supplier, orthosteric, inhibitor, BRCA2, RAD51, interaction, DNA-damage, cancer, PARP1, selective, DNA,, RNA, and, Protein, Synthesis, 7457, Tocris Bioscience

Citations for CAM 833

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Literature in this Area

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