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Submit ReviewCapecitabine
Description: Prodrug of 5-Fluorouracil (Cat. No. 3257). Inhibits DNA synthesis
Alternative Names: Ro 09-1978
Chemical Name: 5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]cytidine
Purity: ≥98% (HPLC)
Biological Activity for Capecitabine
Capecitabine is a prodrug of 5-Fluorouracil (5-FU) (Cat. No. 3257). Selectively activated in tumor cells by thymidine phosphorylase; inhibits DNA synthesis upon conversion to 5-FU. Orally available.
Compound Libraries for Capecitabine
Capecitabine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Capecitabine
| M. Wt | 359.35 |
| Formula | C15H22FN3O6 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 154361-50-9 |
| PubChem ID | 60953 |
| InChI Key | GAGWJHPBXLXJQN-UORFTKCHSA-N |
| Smiles | C[C@H]1O[C@@H](N2C=C(F)C(NC(OCCCCC)=O)=NC2=O)[C@H](O)[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Capecitabine
References for Capecitabine
References are publications that support the biological activity of the product.
Shimma et al (2000) The design and synthesis of a new tumor-selective fluoropyrimidine carbamate, capecitabine. Bioorg.Med.Chem.Lett. 8 1697 PMID: 10976516
Desmoulin et al (2002) Metabolism of capecitabine, an oral fluorou. prodrug: 19F NMR studies in animal models and human urine. Drug Metab.Dispos. 30 1221 PMID: 12386128
Bhuyan et al (1972) Cell cycle phase specificity of antitumor agents. Cancer Res. 32 398 PMID: 4258018
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Citations for Capecitabine
Citations are publications that use Tocris products.
Currently there are no citations for Capecitabine.
Reviews for Capecitabine
Average Rating: 5 (Based on 1 Review.)
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Medium concentrations of capecitabine only weakly slow melanoma growth in vitro.
By
Anonymous on 02/14/2019
Assay Type: In Vitro
Species: Human
Capecitabine was used at a 20 uM concentration for in vitro culture with SK-MEL-28 and cell viability was monitored over time with live imaging. Arrow indicates when compound was added to media.
Literature in this Area
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Cell Cycle and DNA Damage Research Product Guide
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