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Capzimin dimer

Cat. No. 6781 Submit a Review Datasheet / COA / SDS
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Description: Selective proteasome inhibitor
Chemical Name: 8,8'-Dithiobis[N-[2-(2-thiazolyl)ethyl]-3-quinolinecarboxamide]
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Capzimin dimer

Capzimin dimer is a specific inhibitor of proteasome isopeptidase Rpn11 (IC50 = 2.1 μM and 3.8 μM, in 293T and A549 cell lines, respectively). It exhibits 80-fold selectivity for Rpn11 over Csn5, ten-fold over AMSH and six-fold over BRCC36 (IC50 = 30 μM, 4.5 μM, and 2.3 μM, respectively). Capzimin dimer blocks proliferation of cancer cells.

Technical Data for Capzimin dimer

M. Wt 628.8
Formula C30H24N6O2S4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2084868-04-0
PubChem ID 126599606
InChI Key RNEOHKZPZKEZCQ-UHFFFAOYSA-N
Smiles O=C(C1=CC2=C(C(SSC3=CC=CC4=C3N=CC(C(NCCC5=NC=CS5)=O)=C4)=CC=C2)N=C1)NCCC6=NC=CS6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Capzimin dimer

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 62.88 100

Preparing Stock Solutions for Capzimin dimer

The following data is based on the product molecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL
10 mM 0.16 mL 0.8 mL 1.59 mL
50 mM 0.03 mL 0.16 mL 0.32 mL

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Product Datasheets for Capzimin dimer

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for Capzimin dimer

References are publications that support the biological activity of the product.

Perez et al (2017) Discovery of an inhibitor of the proteasome subunit Rpn11. J.Med.Chem. 60 1343 PMID: 28191850

Li et al (2017) Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nat.Chem.Biol. 13 486 PMID: 28244987

If you know of a relevant reference for Capzimin dimer, please let us know.

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Keywords: Capzimin dimer, Capzimin dimer supplier, Selective, proteasome, inhibitor, inhibitors, inhibits, inhibit, isopeptidase, Rpn11, Proteasome, 6781, Tocris Bioscience

Citations for Capzimin dimer

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Literature in this Area

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
  • TAG Degradation Platform
  • Degrader Building Blocks
  • Assays for Protein Degradation
  • Induced Proximity Tools
Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia