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Description: Molecular glue; induces degradation of BCL6
Chemical Name: rel-5-[[5-Chloro-2-[(3R,5S)-4,4-difluoro-3,5-dimethyl-1-piperidinyl]-4-pyrimidinyl]amino]-1,3-dihydro-3-(3-hydroxy-3-methylbutyl)-1-methyl-2H-benzimidazol-2-one
Purity: ≥98% (HPLC)
Biological Activity for CCT 369260
CCT 369260 acts as a potent BCL6 molecular glue Degrader (IC50 = 54 nM). It reduces BCL6 levels in a lymphoma xenograft mouse model. CCT 369260 is orally bioavailable.
Technical Data for CCT 369260
| M. Wt | 509 |
| Formula | C24H31ClF2N6O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2253878-44-1 |
| PubChem ID | 135386938 |
| InChI Key | VFNPUAOAEFMXQI-GASCZTMLSA-N |
| Smiles | CC(C)(O)CCN1C2=CC(NC3=NC(N4C[C@@H](C(F)([C@@H](C4)C)F)C)=NC=C3Cl)=CC=C2N(C1=O)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CCT 369260
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 25.45 | 50 |
Preparing Stock Solutions for CCT 369260
The following data is based on the product molecular weight 509. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.93 mL | 19.65 mL | 39.29 mL |
| 2.5 mM | 0.79 mL | 3.93 mL | 7.86 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.93 mL |
| 25 mM | 0.08 mL | 0.39 mL | 0.79 mL |
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Product Datasheets for CCT 369260
References for CCT 369260
References are publications that support the biological activity of the product.
Bellenie et al (2020) Achieving in vivo target depletion through the discovery and optimization of Benzimidazolone BCL6 degraders. J.Med.Chem. 2020 63 PMID: 32275432
If you know of a relevant reference for CCT 369260, please let us know.
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Keywords: CCT 369260, CCT 369260 supplier, CCT369260, molecular, glue, proteasomal, degraders, inhibitors, inhibit, inhibition, BCL6, ubiquitination, orally, bioavailable, in, vivo, Molecular, Glues, Bcl-2, Family, 7799, Tocris Bioscience
Citations for CCT 369260
Citations are publications that use Tocris products.
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Literature in this Area
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
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