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Submit ReviewCDN 1163
Description: SERCA2 allosteric activator
Chemical Name: 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide
Purity: ≥98% (HPLC)
Biological Activity for CDN 1163
CDN 1163 is a SERCA2 allosteric activator. Increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. Rescues HEK cells from ER stress-induced cell death. Reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. Also improves glucose tolerance and reverses hepatic steatosis in ob/ob mice. Neuroprotective, improves memory and cognition in a mouse Alzheimer's disease model and reduces dyskinesia in rat model of Parkinson's disease. Orally bioavailable.
Compound Libraries for CDN 1163
CDN 1163 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for CDN 1163
| M. Wt | 320.38 |
| Formula | C20H20N2O2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 892711-75-0 |
| PubChem ID | 16016585 |
| InChI Key | GVGVYDCVFBGALZ-UHFFFAOYSA-N |
| Smiles | CC1=NC2=C(NC(C3=CC=C(OC(C)C)C=C3)=O)C=CC=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for CDN 1163
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.04 | 100 | |
| ethanol | 32.04 | 100 |
Preparing Stock Solutions for CDN 1163
The following data is based on the product molecular weight 320.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.12 mL | 15.61 mL | 31.21 mL |
| 5 mM | 0.62 mL | 3.12 mL | 6.24 mL |
| 10 mM | 0.31 mL | 1.56 mL | 3.12 mL |
| 50 mM | 0.06 mL | 0.31 mL | 0.62 mL |
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Product Datasheets for CDN 1163
References for CDN 1163
References are publications that support the biological activity of the product.
Kang et al (2016) Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders. J.Biol.Chem. 291 5185 PMID: 26702054
Krajnak and Dahl et al (2018) A new target for Alzheimer's disease: A small molecule SERCA activator is neuroprotective in vitro and improves memory and cognition in APP/PS1 mice. Bioorg.Med.Chem.Lett. 28 1591 PMID: 29602679
Dahl (2017) A new target for Parkinson's disease: small molecule SERCA activator CDN1163 ameliorates dyskinesia in 6-OHDA-lesioned rats. Bioorg.Med.Chem.Lett. 25 53 PMID: 27776889
If you know of a relevant reference for CDN 1163, please let us know.
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Keywords: CDN 1163, CDN 1163 supplier, CDN1163, allosteric, activators, sarco/endoplasmic, reticulum, Ca2+-ATPase, activates, ER, stress, SERCA2b, type, II, diabetes, T2D, Other, stress/UPR, 5869, Tocris Bioscience
1 Citation for CDN 1163
Citations are publications that use Tocris products. Selected citations for CDN 1163 include:
Ferdek et al (2017) BH3 mimetic-elicited Ca2+ signals in pancreatic acinar cells are dependent on Bax and can be reduced by Ca2+-like peptides. Cell.Death.Dis. 8 PMID: 28252652
Do you know of a great paper that uses CDN 1163 from Tocris? Please let us know.
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