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CG 428-Neg

Cat. No. 7426 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Negative control for CG 428 (Cat. No. 7425)
Chemical Name: 2-(1-Methyl-2,6-dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for CG 428-Neg

Negative control for CG 428 (Cat. No. 7425).

Licensing Information

Sold under license from Cullgen

Technical Data for CG 428-Neg

M. Wt 828.91
Formula C44H45FN10O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2714560-39-9
InChI Key INNUOJBTOZECFW-BONSOQDYSA-N
Smiles FC1=CC=CC([C@H]2CCCN2C3=NN4C(C=C3)=NC=C4C5=NC(N6CCN(C(CCOCCNC7=C8C(N(C(C8=CC=C7)=O)C9CCC(N(C)C9=O)=O)=O)=O)CC6)=CC=C5)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CG 428-Neg

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 82.89 100

Preparing Stock Solutions for CG 428-Neg

The following data is based on the product molecular weight 828.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.21 mL 6.03 mL 12.06 mL
5 mM 0.24 mL 1.21 mL 2.41 mL
10 mM 0.12 mL 0.6 mL 1.21 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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References for CG 428-Neg

References are publications that support the biological activity of the product.

Chen et al (2020) Discovery of first-in-class potent and selective tropomyosin receptor kinase degraders. J.Med.Chem. 63 14562 PMID: 33058680

If you know of a relevant reference for CG 428-Neg, please let us know.

View Related Products by Target

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Citations for CG 428-Neg

Citations are publications that use Tocris products.

Currently there are no citations for CG 428-Neg. Do you know of a great paper that uses CG 428-Neg from Tocris? Please let us know.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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TPD and Induced Proximity Research Product Guide

TPD and Induced Proximity Research Product Guide

This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:

  • Active Degraders
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  • Degrader Building Blocks
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Targeted Protein Degradation Poster

Targeted Protein Degradation Poster

Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia