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CHM 1

Cat. No. 3868 Submit a Review Datasheet / COA / SDS

Discontinued Product

3868 has been discontinued.

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Description: Potent antitumor agent; inducer of apoptosis
Chemical Name: 6-(2-Fluorophenyl)-1,3-dioxolo[4,5-g]quinolin-8(5H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for CHM 1

Inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma. Inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Induces translocation of apoptosis inducing factor (AIF) from the mitochondria to nucleus. Also exhibits vascular targeting activity through upregulation of p53 and induction of death receptor (DR5)-mediated apoptosis in HUVEC cells.

Technical Data for CHM 1

M. Wt 283.25
Formula C16H10FNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 154554-41-3
PubChem ID 375860
InChI Key ZMYDAPJHGNEFGQ-UHFFFAOYSA-N
Smiles O=C2C=C(C3=CC=CC=C3F)NC1=CC4=C(OCO4)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for CHM 1

References are publications that support the biological activity of the product.

Wang et al (2008) CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol.Cancer.Ther. 7 350 PMID: 18281518

Tsai et al (2010) CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J.Biol.Chem. 285 5497 PMID: 20007968

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Citations for CHM 1

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Currently there are no citations for CHM 1.

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Literature in this Area

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Programmed Cell Death Poster

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.

Pathways for CHM 1

Apoptosis Signaling Pathway

Apoptosis Signaling Pathway

Apoptosis is a physiological process for cell death that is critical during aging and development. It may also be referred to as cell 'suicide'. Apoptosis can be triggered by events both inside and outside of the cell.