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Submit ReviewCladribine
Description: Deoxyadenosine analog; pro-apoptotic
Alternative Names: 2-Chloro-2'-deoxyadenosine
Chemical Name: (2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Purity: ≥99% (HPLC)
Biological Activity for Cladribine
Cladribine is an adenosine deaminase (ADA)-resistant analog of deoxyadenosine. Exhibits anti-leukemic activity; Inhibits cell growth of lymphoid and myeloid neoplasm (IC50 = 20 - 87 nM). Pro-apoptotic; induces DNA double-strand breaks. Also inhibits ribonuclease reductase (IC50 = 0.11 - 0.28 μM). Displays activity in vitro and in vivo. Orally bioavailable.
Technical Data for Cladribine
| M. Wt | 285.69 |
| Formula | C10H12ClN5O3 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 4291-63-8 |
| PubChem ID | 20279 |
| InChI Key | PTOAARAWEBMLNO-KVQBGUIXSA-N |
| Smiles | OC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Cladribine
References for Cladribine
References are publications that support the biological activity of the product.
Bryson et al (1993) Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies. Drugs 46 872 PMID: 7507037
Robak et al (2006) Older and new formulations of cladr. Pharmacology and clinical efficacy in hematological malignancies. Recent Pat. Anticancer Drug Discov. 1 23 PMID: 18221024
Seto et al (1985) Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75 377 PMID: 2579098
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Keywords: Cladribine, Cladribine supplier, leukemia, adenosine, deaminase, antileukemic, proapoptotic, ribonuclease, reductase, deoxyadenosine, analogue, analog, 2-Chloro-2-deoxyadenosine, antimetabolites, 2-Chloro-2'-deoxyadenosine, Apoptosis, Inducers, Ribonucleotide, Reductase, 5292, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Cladribine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 Citation for Cladribine
Citations are publications that use Tocris products. Selected citations for Cladribine include:
Weiterer et al (2015) Galactomannan and Zymosan Block the Epinephrine-Induced Particle Transport in Tracheal Epithelium. J Biomed Sci 10 e0143163 PMID: 26571499
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Programmed Cell Death Poster
There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.
Pathways for Cladribine
