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Cordycepin

Cat. No. 2294 1 Citation 1 Review Submit a Review Datasheet / COA / SDS
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Description: RNA synthesis inhibitor
Chemical Name: 3'-Deoxyadenosine
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)
Literature (2)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Cordycepin

Cordycepin is a nucleoside analog that acts as an anticancer and antifungal agent. Can be converted to 3'-deoxyadenosine triphosphate (3'-dATP), which inhibits ATP-dependent DNA synthesis. Inhibits growth of various tumor cells in vitro.

Technical Data for Cordycepin

M. Wt 251.24
Formula C10H13N5O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 73-03-0
PubChem ID 6303
InChI Key OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Smiles NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)C[C@H]3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Cordycepin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.12 100

Preparing Stock Solutions for Cordycepin

The following data is based on the product molecular weight 251.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.98 mL 19.9 mL 39.8 mL
5 mM 0.8 mL 3.98 mL 7.96 mL
10 mM 0.4 mL 1.99 mL 3.98 mL
50 mM 0.08 mL 0.4 mL 0.8 mL

Molarity Calculator

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Product Datasheets for Cordycepin

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References for Cordycepin

References are publications that support the biological activity of the product.

Gumport and Edelhei et al (1976) The synthesis of 3'-dATP and its use as an inhibitor of ATP-dependent DNA synthesis in toluene-treated Escherichia coli. Biochemistry 15 2804 PMID: 779831

Sugar and McCaffrey (1998) Antifungal activity of 3'-deoxyadenosine (cordycepin). Antimicrob.Agents Chemother. 42 1424 PMID: 9624488

Kodama et al (2000) Antileukemic activity and mechanism of action of cordycepin against terminal deoxynucleotidyl transferase-positive (TdT+) leukemic cells. Biochem.Pharmacol. 59 273 PMID: 10609556

If you know of a relevant reference for Cordycepin, please let us know.

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Keywords: Cordycepin, Cordycepin supplier, RNA, synthesis, inhibitors, inhibits, Protein, DNA, DNA,, and, Synthesis, 2294, Tocris Bioscience

1 Citation for Cordycepin

Citations are publications that use Tocris products. Selected citations for Cordycepin include:

Petropoulos et al (2024) Transcription-replication conflicts underlie sensitivity to PARP inhibitors. Nature 628 433 PMID: 38509368

Do you know of a great paper that uses Cordycepin from Tocris? Please let us know.

Reviews for Cordycepin

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Cordycepin inhibits growth of melanoma cell line at micromolar concentrations.
By Anonymous on 02/07/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: SK-MEL-28

Used for killing assay for in vitro cell culture. Cells were cultured for 24 hours before the addition of the compound into the media at low micromolar concentrations (indicated by the arrow).

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Literature in this Area

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