DBeQ

Discontinued Product

4417 has been discontinued.

View all p97 ATPase products.
Description: Selective and reversible p97 ATPase inhibitor
Chemical Name: N2,N4-Bis(phenylmethyl)-2,4-quinazolinediamine
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity for DBeQ

DBeQ is a selective and reversible inhibitor of p97 ATPase (VCP, IC50 = 1.5 μM). Induces executioner caspases (caspase-3 and caspase-7) rapidly. Blocks the degradation of endoplasmic reticulum-associated degradation (ERAD) reporters; also blocks autophagosome maturation and promotes accumulation of LC3-II.

Compound Libraries for DBeQ

DBeQ is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for DBeQ

M. Wt 340.42
Formula C22H20N4
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 177355-84-9
PubChem ID 676352
InChI Key QAIMUUJJAJBPCL-UHFFFAOYSA-N
Smiles C12=CC=CC=C1N=C(NCC4=CC=CC=C4)N=C2NCC3=CC=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for DBeQ

References are publications that support the biological activity of the product.

Chou et al (2011) Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proc.Natl.Acad.Sci.USA 108 4834 PMID: 21383145

Chou and Deshaies (2011) Development of p97 AAA ATPase inhibitors. Autophagy 7 1091 PMID: 21606684

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Keywords: DBeQ, DBeQ supplier, DBeQ, aaa, atpases, p97, reversible, reversibly, selective, inhibitors, inhibits, autophagy, erad, endoplasmic-reticulum, associated, protein, degradation, Autophagy, Other, ER, stress/UPR, ATPase, Translocation, 4417, Tocris Bioscience

2 Citations for DBeQ

Citations are publications that use Tocris products. Selected citations for DBeQ include:

Keith et al (2022) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun 13 4146 PMID: 35842429

Tiwari et al (2016) Caveolin-1 is an aggresome-inducing protein. Sci Rep 6 38681 PMID: 27929047


Reviews for DBeQ

Average Rating: 3 (Based on 1 Review.)

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DbeQ on Dictyostelium mTORC1 signalling.
By Eleanor Warren on 05/23/2019
Assay Type: In Vitro
Species: Other

Treated Dictyostelium cells with DbeQ at 15 uM and 1.5 uM concentrations for 1 hour or 24 hours, and monitored p-4E-BP1 levels as a readout for mTORc1 activity. Did not see any significant difference from control

review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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