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DX3-213B

Cat. No. 8070 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent NDUFS7 antagonist
Chemical Name: (4,4-Difluoro-1-piperidinyl)[(3R)-1-[[4-[(1-methylethyl)sulfonyl]phenyl]sulfonyl]-3-piperidinyl]methanone
Purity: ≥97% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for DX3-213B

DX3-213B is a potent oxidative phosphorylation (OXPHOS) complex I (also known as NDUFS7) antagonist (IC50 = 3.6 nM). DX3-213B impairs ATP generation (IC50 = 11 nM) and inhibits the proliferation of MIA PaCa-2 cells (IC50 = 9 nM) in galactose-containing media. In vivo, DX3-213B significantly delays tumor growth in a syngeneic mouse model of pancreatic cancer. DX3-213B is orally bioavailable.

Licensing Information

Sold under license from the University of Michigan

Technical Data for DX3-213B

M. Wt 478.57
Formula C20H28F2N2O5S2
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 2749555-66-4
PubChem ID 162365370
InChI Key HLSJMSNPBRGRGL-MRXNPFEDSA-N
Smiles O=S(N1C[C@H](C(N2CCC(CC2)(F)F)=O)CCC1)(C3=CC=C(S(C(C)C)(=O)=O)C=C3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for DX3-213B

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.93 50

Preparing Stock Solutions for DX3-213B

The following data is based on the product molecular weight 478.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.18 mL 20.9 mL 41.79 mL
2.5 mM 0.84 mL 4.18 mL 8.36 mL
5 mM 0.42 mL 2.09 mL 4.18 mL
25 mM 0.08 mL 0.42 mL 0.84 mL

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References for DX3-213B

References are publications that support the biological activity of the product.

Xu et al (2023) First-in-class NADH/Ubiquinone oxidoreductase core subunit S7 (NDUFS7) antagonist for the treatment of pancreatic cancer. ACS Pharmacol.Transl.Sci. 6 1164 PMID: 37588763

Xue et al (2022) Multiparameter optimization of oxidative phosphorylation inhibitors for the treatment of pancreatic cancer. J.Med.Chem. 65 3404 PMID: 35167303

If you know of a relevant reference for DX3-213B, please let us know.

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Keywords: DX3-213B, DX3-213B supplier, OXPHOS, potent, orally, bioavailable, complex, 1, antogonist, oxidative, phosphorylation, pancreatic, cancer, in, vivo, NDUFS7, Oxidative, Phosphorylation, 8070, Tocris Bioscience

Citations for DX3-213B

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