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Submit RevieweIF4A i28 is a eukaryotic initiation factor-4A (eIF4A) inhibitor (IC50 = 8.60 μM in an eIF4A ATPase assay). It decreases BJAB Burkitt lymphoma cell viability (EC50 = 0.46 μM in a CellTiter-Glo (CTG) luminescence cell viability assay. It acts as an RNA-competitive, ATP-uncompetitive eIF4A inhibitor.
Sold under license from the University of Arizona
M. Wt | 416.43 |
Formula | C24H20N2O5 |
Storage | Store at -20°C |
Purity | ≥98% (HPLC) |
CAS Number | 2861994-92-3 |
PubChem ID | 163198549 |
InChI Key | UDCAKLDMNJRQKW-UHFFFAOYSA-N |
Smiles | CCCCC1=CC=C(C2=CC=C(C3=NC4=CC=C(C=C4C(C(O)=O)=C3)[N+]([O-])=O)O2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.33 | 20 |
The following data is based on the product molecular weight 416.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.2 mM | 12.01 mL | 60.03 mL | 120.07 mL |
1 mM | 2.4 mL | 12.01 mL | 24.01 mL |
2 mM | 1.2 mL | 6 mL | 12.01 mL |
10 mM | 0.24 mL | 1.2 mL | 2.4 mL |
References are publications that support the biological activity of the product.
Zerio et al (2021) Discovery of an eIF4A inhibitor with a novel mechanism of action. J.Med.Chem. 64 15727 PMID: 34676755
If you know of a relevant reference for eIF4A i28, please let us know.
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