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Description: Molecular glue; induces degradation of NQAT1
Alternative Names: Selective NTAQ1 degrader
Chemical Name: 3-[6-[(Fluorosulfonyl)oxy]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Biological Activity for EM 12-FS
EM12-FS is a selective N-terminal glutamine amidohydrolase 1 (NTAQ1) Degrader. In MOLT4 cells, it downregulates NTAQ1 via cereblon-mediated degradation (IC50 = 256 nM). Requires covalent His353 engagement to recruit and degrade NTAQ1.
Technical Data for EM 12-FS
| M. Wt | 342.3 |
| Formula | C13H11FN2O6S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2839138-44-0 |
| PubChem ID | 165879822 |
| InChI Key | RXYXBYLQECASPH-UHFFFAOYSA-N |
| Smiles | O=C1NC(C(CC1)N2C(C3=CC(OS(=O)(F)=O)=CC=C3C2)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for EM 12-FS
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.23 | 100 |
Preparing Stock Solutions for EM 12-FS
The following data is based on the product molecular weight 342.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.61 mL | 29.21 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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Product Datasheets for EM 12-FS
References for EM 12-FS
References are publications that support the biological activity of the product.
Cruite et al (2022) Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem.Biol. 3 1105 PMID: 36128501
If you know of a relevant reference for EM 12-FS, please let us know.
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Citations for EM 12-FS
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Literature in this Area
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TPD and Induced Proximity Research Product GuideUpdated
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