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Discontinued Product
4495 has been discontinued.
Description: γ-secretase inhibitor; lowers Aβ42 levels in vitro
Alternative Names: (R)-Flurbiprofen
Chemical Name: (R)-2-Fluoro-α-methyl[1,1'-biphenyl]-4-acetic acid
Purity: ≥99% (HPLC)
Biological Activity for Flurizan
Nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity. Selectively lowers Aβ42 levels in human neuroglioma cells; displays no effect on Aβ40 levels at a concentration of 100 μM.
Technical Data for Flurizan
| M. Wt | 244.26 |
| Formula | C15H13FO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 51543-40-9 |
| PubChem ID | 92337 |
| InChI Key | SYTBZMRGLBWNTM-SNVBAGLBSA-N |
| Smiles | FC1=C(C2=CC=CC=C2)C=CC([C@@H](C)C(O)=O)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Flurizan
References for Flurizan
References are publications that support the biological activity of the product.
Eriksen et al (2003) NSAIDs and enantiomers of flurbip. target γ-secretase and lower Aβ42 in vivo. J.Clin.Invest. 112 440 PMID: 12897211
Kukar et al (2007) Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci. 8 54 PMID: 17650315
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Citations for Flurizan
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Currently there are no citations for Flurizan.
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