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Submit ReviewGaliellalactone
Description: STAT3 inhibitor; active in vivo
Chemical Name: (4S,5aR,7aR,7bS)-5,5a,6,7,7a,7b-Hexahydro-7b-hydroxy-4-methylindeno[1,7-bc]furan-2(4H)-one
Purity: ≥95% (HPLC)
Biological Activity for Galiellalactone
Galiellalactone is a STAT3 inhibitor. Irreversibly binds STAT3 and inhibits binding to DNA. Inhibits IL-6-dependent JAK/STAT signaling. Induces cell-cycle arrest in G2/M phase and apoptosis in androgen-insensitive prostate cancer cells via activation of ATM/ATR pathway. Also destabilizes microtubules and inhibits cell migration. Exhibits anticancer effects in a mouse tumor xenograft model.
Technical Data for Galiellalactone
| M. Wt | 194.23 |
| Formula | C11H14O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 133613-71-5 |
| PubChem ID | 3698011 |
| InChI Key | SOIISBQQYAGDKM-UHFFFAOYSA-N |
| Smiles | [H][C@@]12CC[C@]3(OC(C([C@@]23O)=C[C@H](C1)C)=O)[H] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Galiellalactone
References for Galiellalactone
References are publications that support the biological activity of the product.
Don-Doncow et al (2014) Galiellalactone is a direct inhibitor of the transcription factor STAT3 in prostate cancer cells. J.Biol.Chem. 289 15969 PMID: 24755219
Weilder et al (2000) Inhibition of interleukin-6 signaling by galiellalactone. FEBS Lett. 484 1 PMID: 11056211
Garcia et al (2016) Galiellalactone induces cell cycle arrest and apoptosis through the ATM/ATR pathway in prostate cancer cells. Oncotarget 7 4490 PMID: 26683224
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Keywords: Galiellalactone, Galiellalactone supplier, STAT3, inhibitors, inhibits, IL-6, signaling, anticancer, in, vivo, active, STAT, 6218, Tocris Bioscience
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Pathways for Galiellalactone
