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Submit ReviewHJC 0416 hydrochloride
Description: STAT3 inhibitor
Chemical Name: 2-(3-Aminopropoxy)-5-chloro-N-(1,1-dioxidobenzo[b]thien-6-yl)benzamide hydrochloride
Purity: ≥97% (HPLC)
Biological Activity for HJC 0416 hydrochloride
HJC 0416 hydrochloride is a STAT3 inhibitor. Downregulates phosphorylation of STAT3 and increases the expression of cleaved caspase-3. Inhibits cell-cycle progression and proliferation in breast and pancreatic cancer cells in vitro (IC50 values are in the range 0.04 - 1.97 μM). Also inhibits growth of ER-negative breast cancer xenografts in mice. Orally bioavailable.
Compound Libraries for HJC 0416 hydrochloride
HJC 0416 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for HJC 0416 hydrochloride
| M. Wt | 429.32 |
| Formula | C18H17ClN2O4S.HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 2415263-08-8 |
| InChI Key | YWFDTXJORDWLGD-UHFFFAOYSA-N |
| Smiles | ClC(C=C1)=CC(C(NC2=CC=C3C=CS(=O)(C3=C2)=O)=O)=C1OCCCN.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HJC 0416 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.93 | 100 | |
| water | 8.59 | 20 |
Preparing Stock Solutions for HJC 0416 hydrochloride
The following data is based on the product molecular weight 429.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.65 mL | 23.29 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for HJC 0416 hydrochloride
References for HJC 0416 hydrochloride
References are publications that support the biological activity of the product.
Chen et al (2014) Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur.J.Med.Chem. 82 195 PMID: 24904966
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